Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease
Abstract We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified into severe (n = 25) and non-severe (n = 69)...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17032-2 |
| _version_ | 1818162667843485696 |
|---|---|
| author | Hyeon-Jeong Yoon Ga-Young Song Kyung Chul Yoon |
| author_facet | Hyeon-Jeong Yoon Ga-Young Song Kyung Chul Yoon |
| author_sort | Hyeon-Jeong Yoon |
| collection | DOAJ |
| description | Abstract We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified into severe (n = 25) and non-severe (n = 69) groups. Factors associated with oGVHD severity and poor vision outcomes were examined using multivariate logistic regression. In the severe oGVHD group, the disease activity pattern tended to be persistent, whereas flare-up episodes were more frequent and occurred over shorter intervals in this group. Myelodysplastic syndrome (MDS) and lung GVHD were more common and systemic calcineurin inhibitors were used more frequently in the severe group than in the non-severe group. Finally, 5-year survival rates were poorer in the severe group. Multivariate analysis revealed that MDS, lung GVHD involvement, and no history of systemic calcineurin inhibitor use were risk factors for severe oGVHD. Risk factors for poor vision outcomes were conjunctival scarring and persistent epithelial defects. In conclusion, MDS, lung GVHD, and no history of systemic calcineurin inhibitors are associated with severe oGVHD. Conjunctival scarring and persistent epithelial defects are risk factors for poor vision outcomes. |
| first_indexed | 2024-12-11T16:37:19Z |
| format | Article |
| id | doaj.art-dc3118ed20324ab3bf6ea2785a9d9cac |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-11T16:37:19Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-dc3118ed20324ab3bf6ea2785a9d9cac2022-12-22T00:58:25ZengNature PortfolioScientific Reports2045-23222022-07-011211910.1038/s41598-022-17032-2Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host diseaseHyeon-Jeong Yoon0Ga-Young Song1Kyung Chul Yoon2Department of Ophthalmology, Chonnam National University Medical School and HospitalDepartment of Hematology-Oncology, Chonnam National University Hwasun HospitalDepartment of Ophthalmology, Chonnam National University Medical School and HospitalAbstract We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified into severe (n = 25) and non-severe (n = 69) groups. Factors associated with oGVHD severity and poor vision outcomes were examined using multivariate logistic regression. In the severe oGVHD group, the disease activity pattern tended to be persistent, whereas flare-up episodes were more frequent and occurred over shorter intervals in this group. Myelodysplastic syndrome (MDS) and lung GVHD were more common and systemic calcineurin inhibitors were used more frequently in the severe group than in the non-severe group. Finally, 5-year survival rates were poorer in the severe group. Multivariate analysis revealed that MDS, lung GVHD involvement, and no history of systemic calcineurin inhibitor use were risk factors for severe oGVHD. Risk factors for poor vision outcomes were conjunctival scarring and persistent epithelial defects. In conclusion, MDS, lung GVHD, and no history of systemic calcineurin inhibitors are associated with severe oGVHD. Conjunctival scarring and persistent epithelial defects are risk factors for poor vision outcomes.https://doi.org/10.1038/s41598-022-17032-2 |
| spellingShingle | Hyeon-Jeong Yoon Ga-Young Song Kyung Chul Yoon Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease Scientific Reports |
| title | Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease |
| title_full | Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease |
| title_fullStr | Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease |
| title_full_unstemmed | Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease |
| title_short | Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease |
| title_sort | long term clinical outcomes and predictive factors in patients with chronic ocular graft versus host disease |
| url | https://doi.org/10.1038/s41598-022-17032-2 |
| work_keys_str_mv | AT hyeonjeongyoon longtermclinicaloutcomesandpredictivefactorsinpatientswithchronicoculargraftversushostdisease AT gayoungsong longtermclinicaloutcomesandpredictivefactorsinpatientswithchronicoculargraftversushostdisease AT kyungchulyoon longtermclinicaloutcomesandpredictivefactorsinpatientswithchronicoculargraftversushostdisease |