Sensitivity of different DNA extraction methods and PCR to detect resistance in patients with leprosy stratified by the bacilloscopic index

Sensitivity of different DNA extraction methods and PCR to detect resistance in patients with leprosy stratified by the bacilloscopic index

Introduction: Antimicrobial resistance in leprosy is an emerging problem, and the quantitative impact of low bacilloscopic indexes (BIs) on the sensitivity of molecular tests is unknown. We aimed to evaluate the sensitivity of gene sequencing for the detection of mutations related to antimicrobial r...

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Bibliographic Details
Main Authors: Lais Sevilha-Santos, Danielle Costa Aquino, Günter Hans Neto, Fabiano José Queiroz Costa, Carlos Augusto Felipe de Sousa, Elaine Faria Morelo, Agenor de Castro Moreira dos Santos Júnior, Ciro Martins Gomes
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Brazilian Journal of Infectious Diseases
Subjects:
Leprosy
Microbial sensitivity tests
Polymerase chain reaction
Therapeutics
Bacilloscopic index
DNA extraction
Online Access:http://www.sciencedirect.com/science/article/pii/S141386702200068X

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http://www.sciencedirect.com/science/article/pii/S141386702200068X

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