Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms
Vitamin B6 is a cofactor for approximately 150 reactions that regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, it plays the role of antioxidant by counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products (AGEs)....
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/10/3669 |
| _version_ | 1797567255470407680 |
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| author | Elisa Mascolo Fiammetta Vernì |
| author_facet | Elisa Mascolo Fiammetta Vernì |
| author_sort | Elisa Mascolo |
| collection | DOAJ |
| description | Vitamin B6 is a cofactor for approximately 150 reactions that regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, it plays the role of antioxidant by counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products (AGEs). Epidemiological and experimental studies indicated an evident inverse association between vitamin B6 levels and diabetes, as well as a clear protective effect of vitamin B6 on diabetic complications. Interestingly, by exploring the mechanisms that govern the relationship between this vitamin and diabetes, vitamin B6 can be considered both a cause and effect of diabetes. This review aims to report the main evidence concerning the role of vitamin B6 in diabetes and to examine the underlying molecular and cellular mechanisms. In addition, the relationship between vitamin B6, genome integrity, and diabetes is examined. The protective role of this vitamin against diabetes and cancer is discussed. |
| first_indexed | 2024-03-10T19:39:05Z |
| format | Article |
| id | doaj.art-dc31a1e78bfc4d1d96a241ea3af19888 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:39:05Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dc31a1e78bfc4d1d96a241ea3af198882023-11-20T01:29:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110366910.3390/ijms21103669Vitamin B6 and Diabetes: Relationship and Molecular MechanismsElisa Mascolo0Fiammetta Vernì1Department of Biology and Biotechnology “Charles Darwin”, Sapienza University, 00185 Roma, ItalyDepartment of Biology and Biotechnology “Charles Darwin”, Sapienza University, 00185 Roma, ItalyVitamin B6 is a cofactor for approximately 150 reactions that regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, it plays the role of antioxidant by counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products (AGEs). Epidemiological and experimental studies indicated an evident inverse association between vitamin B6 levels and diabetes, as well as a clear protective effect of vitamin B6 on diabetic complications. Interestingly, by exploring the mechanisms that govern the relationship between this vitamin and diabetes, vitamin B6 can be considered both a cause and effect of diabetes. This review aims to report the main evidence concerning the role of vitamin B6 in diabetes and to examine the underlying molecular and cellular mechanisms. In addition, the relationship between vitamin B6, genome integrity, and diabetes is examined. The protective role of this vitamin against diabetes and cancer is discussed.https://www.mdpi.com/1422-0067/21/10/3669vitamin B6diabetesAGEs |
| spellingShingle | Elisa Mascolo Fiammetta Vernì Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms International Journal of Molecular Sciences vitamin B6 diabetes AGEs |
| title | Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms |
| title_full | Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms |
| title_fullStr | Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms |
| title_full_unstemmed | Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms |
| title_short | Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms |
| title_sort | vitamin b6 and diabetes relationship and molecular mechanisms |
| topic | vitamin B6 diabetes AGEs |
| url | https://www.mdpi.com/1422-0067/21/10/3669 |
| work_keys_str_mv | AT elisamascolo vitaminb6anddiabetesrelationshipandmolecularmechanisms AT fiammettaverni vitaminb6anddiabetesrelationshipandmolecularmechanisms |