Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival
Programmed cell death protein-1 (PD-1) is an inhibitory co-receptor required for regulating immune responsiveness and maintaining immune homeostasis. As PD-1 can be released as bioactive soluble molecule, we investigated the clinical significance of soluble PD-1 (sPD-1) after allogeneic hematopoieti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.694843/full |
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| author | Lambros Kordelas Ulrike Buttkereit Falko M. Heinemann Peter A. Horn Bernd Giebel Dietrich W. Beelen H. Christian Reinhardt Vera Rebmann |
| author_facet | Lambros Kordelas Ulrike Buttkereit Falko M. Heinemann Peter A. Horn Bernd Giebel Dietrich W. Beelen H. Christian Reinhardt Vera Rebmann |
| author_sort | Lambros Kordelas |
| collection | DOAJ |
| description | Programmed cell death protein-1 (PD-1) is an inhibitory co-receptor required for regulating immune responsiveness and maintaining immune homeostasis. As PD-1 can be released as bioactive soluble molecule, we investigated the clinical significance of soluble PD-1 (sPD-1) after allogeneic hematopoietic stem cell transplantation (HSCT) regarding graft-versus-host disease (GvHD), relapse, and overall survival (OS) in a mono-centric cohort of 82 patients. Compared to pre-HSCT and to healthy controls, post-HSCT sPD-1 plasma levels were significantly increased during an observation time of three months. Univariate analysis revealed that low sPD-1 plasma levels at month one, two or three post HSCT were associated with acute GvHD grade III-IV, the onset of moderate/severe chronic GvHD (cGvHD) and inferior OS, DFS, and TRM, respectively. No relationship was detected to relapse rates. sPD-1 plasma levels were significantly increased in ATG-treated patients compared to ATG-untreated patients. Multivariate analysis revealed that a low sPD-1 plasma levels status at one or two month(s) after HSCT is an independent indicator for inferior OS, DFS, or TRM. A low sPD-1 plasma levels status at month three post HSCT is predictive for the onset of moderate/severe cGvHD. Thus, our study pinpoints the soluble inhibitory co-receptor PD-1 as a promising candidate molecule for the prediction of clinical HSCT outcome. |
| first_indexed | 2024-12-17T19:44:10Z |
| format | Article |
| id | doaj.art-dc328b489a3d46c7afda37718abd0c50 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T19:44:10Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dc328b489a3d46c7afda37718abd0c502022-12-21T21:34:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-09-011210.3389/fimmu.2021.694843694843Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall SurvivalLambros Kordelas0Ulrike Buttkereit1Falko M. Heinemann2Peter A. Horn3Bernd Giebel4Dietrich W. Beelen5H. Christian Reinhardt6Vera Rebmann7Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, GermanyDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, GermanyInstitute for Transfusion Medicine, University Hospital Essen, Essen, GermanyInstitute for Transfusion Medicine, University Hospital Essen, Essen, GermanyInstitute for Transfusion Medicine, University Hospital Essen, Essen, GermanyDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, GermanyDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, GermanyInstitute for Transfusion Medicine, University Hospital Essen, Essen, GermanyProgrammed cell death protein-1 (PD-1) is an inhibitory co-receptor required for regulating immune responsiveness and maintaining immune homeostasis. As PD-1 can be released as bioactive soluble molecule, we investigated the clinical significance of soluble PD-1 (sPD-1) after allogeneic hematopoietic stem cell transplantation (HSCT) regarding graft-versus-host disease (GvHD), relapse, and overall survival (OS) in a mono-centric cohort of 82 patients. Compared to pre-HSCT and to healthy controls, post-HSCT sPD-1 plasma levels were significantly increased during an observation time of three months. Univariate analysis revealed that low sPD-1 plasma levels at month one, two or three post HSCT were associated with acute GvHD grade III-IV, the onset of moderate/severe chronic GvHD (cGvHD) and inferior OS, DFS, and TRM, respectively. No relationship was detected to relapse rates. sPD-1 plasma levels were significantly increased in ATG-treated patients compared to ATG-untreated patients. Multivariate analysis revealed that a low sPD-1 plasma levels status at one or two month(s) after HSCT is an independent indicator for inferior OS, DFS, or TRM. A low sPD-1 plasma levels status at month three post HSCT is predictive for the onset of moderate/severe cGvHD. Thus, our study pinpoints the soluble inhibitory co-receptor PD-1 as a promising candidate molecule for the prediction of clinical HSCT outcome.https://www.frontiersin.org/articles/10.3389/fimmu.2021.694843/fullallogeneic hematopoietic stem cell transplantationgraft-versus-host diseasePD-1soluble PD-1immune checkpointinhibitory co-receptor |
| spellingShingle | Lambros Kordelas Ulrike Buttkereit Falko M. Heinemann Peter A. Horn Bernd Giebel Dietrich W. Beelen H. Christian Reinhardt Vera Rebmann Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival Frontiers in Immunology allogeneic hematopoietic stem cell transplantation graft-versus-host disease PD-1 soluble PD-1 immune checkpoint inhibitory co-receptor |
| title | Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival |
| title_full | Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival |
| title_fullStr | Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival |
| title_full_unstemmed | Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival |
| title_short | Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival |
| title_sort | low soluble programmed cell death protein 1 levels after allogeneic stem cell transplantation predict moderate or severe chronic gvhd and inferior overall survival |
| topic | allogeneic hematopoietic stem cell transplantation graft-versus-host disease PD-1 soluble PD-1 immune checkpoint inhibitory co-receptor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.694843/full |
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