Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC
A major part of non-small cell lung cancer (NSCLC) patients treated with mono- or multimodal concept develop therapy resistance. Despite the abundance of biomarkers investigated in the past, there is still a need for valid NSCLC biomarkers. Glycodelin, an immunosuppressive endometrial protein, has b...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/10/12/486 |
| _version_ | 1797708221680451584 |
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| author | Marc A. Schneider Thomas Muley Rebecca Weber Sabine Wessels Michael Thomas Felix J. F. Herth Nicolas C. Kahn Ralf Eberhardt Hauke Winter Gudula Heussel Arne Warth Christel Herold-Mende Michael Meister |
| author_facet | Marc A. Schneider Thomas Muley Rebecca Weber Sabine Wessels Michael Thomas Felix J. F. Herth Nicolas C. Kahn Ralf Eberhardt Hauke Winter Gudula Heussel Arne Warth Christel Herold-Mende Michael Meister |
| author_sort | Marc A. Schneider |
| collection | DOAJ |
| description | A major part of non-small cell lung cancer (NSCLC) patients treated with mono- or multimodal concept develop therapy resistance. Despite the abundance of biomarkers investigated in the past, there is still a need for valid NSCLC biomarkers. Glycodelin, an immunosuppressive endometrial protein, has been shown to be also expressed in NSCLC. Here, we investigated its potential as a biomarker in metastatic and advanced stage NSCLC. Glycodelin gene and protein expression were measured in 28 therapy-naïve resected tumors as well as in corresponding brain (<i>n</i> = 16) and adrenal gland (<i>n</i> = 12) metastasis by qPCR and IHC. Moreover, we correlated glycodelin gene expression of cryoconserved therapy-naïve biopsies (<i>n</i> = 55) of advanced stage patients with glycodelin serum concentrations and patient survival. Using follow-up samples of the patients, we monitored glycodelin serum concentrations during therapy. Glycodelin expression correlated between primary tumor and distant metastases within the same patients. The gene expression of glycodelin in therapy-naïve biopsies also correlated with the serum concentrations of the patients (r = 0.60). Patients with elevated serum concentrations showed a tendency in lower overall survival (<i>p</i> = 0.088) and measuring of glycodelin indicated a progression of the disease earlier compared to clinical diagnostic. Taken together, we demonstrate that glycodelin is a promising prognostic and follow-up biomarker for metastatic and advanced NSCLC. |
| first_indexed | 2024-03-12T06:19:12Z |
| format | Article |
| id | doaj.art-dc32ac677b8f43a5a38d3f2d9f44068b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:19:12Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dc32ac677b8f43a5a38d3f2d9f44068b2023-09-03T02:23:17ZengMDPI AGCancers2072-66942018-12-01101248610.3390/cancers10120486cancers10120486Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLCMarc A. Schneider0Thomas Muley1Rebecca Weber2Sabine Wessels3Michael Thomas4Felix J. F. Herth5Nicolas C. Kahn6Ralf Eberhardt7Hauke Winter8Gudula Heussel9Arne Warth10Christel Herold-Mende11Michael Meister12Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, GermanyTranslational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, GermanyTranslational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, GermanyInstitute of Pathology, University Hospital Heidelberg, D-69120 Heidelberg, GermanyDivision of Experimental Neurosurgery, Heidelberg University Hospital, D-69120 Heidelberg, GermanyTranslational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, GermanyA major part of non-small cell lung cancer (NSCLC) patients treated with mono- or multimodal concept develop therapy resistance. Despite the abundance of biomarkers investigated in the past, there is still a need for valid NSCLC biomarkers. Glycodelin, an immunosuppressive endometrial protein, has been shown to be also expressed in NSCLC. Here, we investigated its potential as a biomarker in metastatic and advanced stage NSCLC. Glycodelin gene and protein expression were measured in 28 therapy-naïve resected tumors as well as in corresponding brain (<i>n</i> = 16) and adrenal gland (<i>n</i> = 12) metastasis by qPCR and IHC. Moreover, we correlated glycodelin gene expression of cryoconserved therapy-naïve biopsies (<i>n</i> = 55) of advanced stage patients with glycodelin serum concentrations and patient survival. Using follow-up samples of the patients, we monitored glycodelin serum concentrations during therapy. Glycodelin expression correlated between primary tumor and distant metastases within the same patients. The gene expression of glycodelin in therapy-naïve biopsies also correlated with the serum concentrations of the patients (r = 0.60). Patients with elevated serum concentrations showed a tendency in lower overall survival (<i>p</i> = 0.088) and measuring of glycodelin indicated a progression of the disease earlier compared to clinical diagnostic. Taken together, we demonstrate that glycodelin is a promising prognostic and follow-up biomarker for metastatic and advanced NSCLC.https://www.mdpi.com/2072-6694/10/12/486<i>PAEP</i>glycodelinNSCLCearly detectionfollow-up biomarker |
| spellingShingle | Marc A. Schneider Thomas Muley Rebecca Weber Sabine Wessels Michael Thomas Felix J. F. Herth Nicolas C. Kahn Ralf Eberhardt Hauke Winter Gudula Heussel Arne Warth Christel Herold-Mende Michael Meister Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC Cancers <i>PAEP</i> glycodelin NSCLC early detection follow-up biomarker |
| title | Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC |
| title_full | Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC |
| title_fullStr | Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC |
| title_full_unstemmed | Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC |
| title_short | Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC |
| title_sort | glycodelin as a serum and tissue biomarker for metastatic and advanced nsclc |
| topic | <i>PAEP</i> glycodelin NSCLC early detection follow-up biomarker |
| url | https://www.mdpi.com/2072-6694/10/12/486 |
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