Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma
Preoperative detection of cervical lymph node metastasis in papillary thyroid carcinoma (PTC) is crucial for determining the surgical strategy to prevent locoregional recurrence of the disease. We identified the cytological predictors of lymph node metastasis in 222 consecutive patients with PTC usi...
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MDPI AG
2019-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/6/816 |
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| author | Ji Eun Choi Ja Seong Bae Dong-Jun Lim So Lyung Jung Chan Kwon Jung |
| author_facet | Ji Eun Choi Ja Seong Bae Dong-Jun Lim So Lyung Jung Chan Kwon Jung |
| author_sort | Ji Eun Choi |
| collection | DOAJ |
| description | Preoperative detection of cervical lymph node metastasis in papillary thyroid carcinoma (PTC) is crucial for determining the surgical strategy to prevent locoregional recurrence of the disease. We identified the cytological predictors of lymph node metastasis in 222 consecutive patients with PTC using fine-needle aspiration cytology (FNAC) of the thyroid. Cervical lymph node metastases occurred in 99 (44.6%) of 222 PTC patients. Lymph node metastasis was significantly associated with tumor multifocality (<i>p</i> = 0.003), and high cellularity (<i>p</i> = 0.021), atypical histiocytoid cells (<i>p</i> < 0.001), and multinucleated giant cells (<i>p</i> < 0.001) in thyroid FNAC. The <i>BRAF</i> V600E mutation was marginally associated with lymph node metastasis (<i>p</i> = 0.054). Multivariate analysis revealed that atypical histiocytoid cells (odds ratio = 2.717; <i>p</i> = 0.001) and multinucleated giant cells (odds ratio = 3.070; <i>p</i> = 0.031) were independent predictors of lymph node metastasis in patients with PTC. In a subgroup analysis of 164 patients with microcarcinomas, atypical histiocytoid cells (odds ratio = 2.761; <i>p</i> = 0.005) was an independent predictor of lymph node metastasis. Cytological detection of atypical histiocytoid cells and multinucleated giant cells on thyroid FNAC can be used to preoperatively predict cervical lymph node metastasis in patients with PTC. |
| first_indexed | 2024-03-12T09:49:32Z |
| format | Article |
| id | doaj.art-dc34b7a5d5624a5ab32aae153c87663d |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:49:32Z |
| publishDate | 2019-06-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dc34b7a5d5624a5ab32aae153c87663d2023-09-02T12:40:18ZengMDPI AGCancers2072-66942019-06-0111681610.3390/cancers11060816cancers11060816Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid CarcinomaJi Eun Choi0Ja Seong Bae1Dong-Jun Lim2So Lyung Jung3Chan Kwon Jung4Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaCancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaCancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Radiology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaPreoperative detection of cervical lymph node metastasis in papillary thyroid carcinoma (PTC) is crucial for determining the surgical strategy to prevent locoregional recurrence of the disease. We identified the cytological predictors of lymph node metastasis in 222 consecutive patients with PTC using fine-needle aspiration cytology (FNAC) of the thyroid. Cervical lymph node metastases occurred in 99 (44.6%) of 222 PTC patients. Lymph node metastasis was significantly associated with tumor multifocality (<i>p</i> = 0.003), and high cellularity (<i>p</i> = 0.021), atypical histiocytoid cells (<i>p</i> < 0.001), and multinucleated giant cells (<i>p</i> < 0.001) in thyroid FNAC. The <i>BRAF</i> V600E mutation was marginally associated with lymph node metastasis (<i>p</i> = 0.054). Multivariate analysis revealed that atypical histiocytoid cells (odds ratio = 2.717; <i>p</i> = 0.001) and multinucleated giant cells (odds ratio = 3.070; <i>p</i> = 0.031) were independent predictors of lymph node metastasis in patients with PTC. In a subgroup analysis of 164 patients with microcarcinomas, atypical histiocytoid cells (odds ratio = 2.761; <i>p</i> = 0.005) was an independent predictor of lymph node metastasis. Cytological detection of atypical histiocytoid cells and multinucleated giant cells on thyroid FNAC can be used to preoperatively predict cervical lymph node metastasis in patients with PTC.https://www.mdpi.com/2072-6694/11/6/816thyroid cytopathologyliquid-based preparationfine needle aspirationpapillary carcinomalymph node metastasis |
| spellingShingle | Ji Eun Choi Ja Seong Bae Dong-Jun Lim So Lyung Jung Chan Kwon Jung Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma Cancers thyroid cytopathology liquid-based preparation fine needle aspiration papillary carcinoma lymph node metastasis |
| title | Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma |
| title_full | Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma |
| title_fullStr | Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma |
| title_full_unstemmed | Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma |
| title_short | Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma |
| title_sort | atypical histiocytoid cells and multinucleated giant cells in fine needle aspiration cytology of the thyroid predict lymph node metastasis of papillary thyroid carcinoma |
| topic | thyroid cytopathology liquid-based preparation fine needle aspiration papillary carcinoma lymph node metastasis |
| url | https://www.mdpi.com/2072-6694/11/6/816 |
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