Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study
Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were e...
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Sociedade Brasileira de Pesquisa Odontológica
2023-05-01
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| Series: | Brazilian Oral Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242023000100240&lng=en&tlng=en |
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| author | Laura Borges KIRSCHNICK Felipe Martins SILVEIRA Lauren Frenzel SCHUCH Ana Carolina Uchoa VASCONCELOS Ana Paula GOMES Jean Nunes dos SANTOS Dandara Andrade SANTANA Felipe Paiva FONSECA Ricardo Alves MESQUITA Elismauro Francisco de MENDONÇA Sebastião Silvério SOUSA-NETO Hélder Antônio Rebelo PONTES Liam ROBINSON Willie van HEERDEN Román CARLOS-BREGNI Elena María José Román TAGER Luan César da SILVA Virgílio Gonzales ZANELLA Luis Fernando RIVERO Raquel BITTENCOURT Marco Antonio Trevizani MARTINS Márcio Ajudarte LOPES Vivian Petersen WAGNER Pablo Agustin VARGAS Manoela Domingues MARTINS |
| author_facet | Laura Borges KIRSCHNICK Felipe Martins SILVEIRA Lauren Frenzel SCHUCH Ana Carolina Uchoa VASCONCELOS Ana Paula GOMES Jean Nunes dos SANTOS Dandara Andrade SANTANA Felipe Paiva FONSECA Ricardo Alves MESQUITA Elismauro Francisco de MENDONÇA Sebastião Silvério SOUSA-NETO Hélder Antônio Rebelo PONTES Liam ROBINSON Willie van HEERDEN Román CARLOS-BREGNI Elena María José Román TAGER Luan César da SILVA Virgílio Gonzales ZANELLA Luis Fernando RIVERO Raquel BITTENCOURT Marco Antonio Trevizani MARTINS Márcio Ajudarte LOPES Vivian Petersen WAGNER Pablo Agustin VARGAS Manoela Domingues MARTINS |
| author_sort | Laura Borges KIRSCHNICK |
| collection | DOAJ |
| description | Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region. |
| first_indexed | 2024-03-13T08:44:33Z |
| format | Article |
| id | doaj.art-dc3519fb16744d70aeefa11cc5f0851a |
| institution | Directory Open Access Journal |
| issn | 1807-3107 |
| language | English |
| last_indexed | 2024-03-13T08:44:33Z |
| publishDate | 2023-05-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj.art-dc3519fb16744d70aeefa11cc5f0851a2023-05-30T07:34:29ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072023-05-013710.1590/1807-3107bor-2023.vol37.0050Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter studyLaura Borges KIRSCHNICKhttps://orcid.org/0000-0002-9411-3713Felipe Martins SILVEIRAhttps://orcid.org/0000-0001-9834-5194Lauren Frenzel SCHUCHhttps://orcid.org/0000-0002-0993-936XAna Carolina Uchoa VASCONCELOShttps://orcid.org/0000-0001-6560-9536Ana Paula GOMEShttps://orcid.org/0000-0003-2214-5246Jean Nunes dos SANTOShttps://orcid.org/0000-0001-7225-5879Dandara Andrade SANTANAhttps://orcid.org/0000-0002-9060-2907Felipe Paiva FONSECAhttps://orcid.org/0000-0002-6657-4547Ricardo Alves MESQUITAhttps://orcid.org/0000-0002-5317-7390Elismauro Francisco de MENDONÇAhttps://orcid.org/0000-0002-6751-3279Sebastião Silvério SOUSA-NETOhttps://orcid.org/0000-0001-8890-8723Hélder Antônio Rebelo PONTEShttps://orcid.org/0000-0002-7609-8804Liam ROBINSONhttps://orcid.org/0000-0002-0549-7824Willie van HEERDENhttps://orcid.org/0000-0003-2494-667XRomán CARLOS-BREGNIhttps://orcid.org/0000-0003-1022-8087Elena María José Román TAGERhttps://orcid.org/0000-0003-0891-9284Luan César da SILVAhttps://orcid.org/0000-0001-9551-946XVirgílio Gonzales ZANELLAhttps://orcid.org/0000-0001-5721-9968Luis Fernando RIVEROhttps://orcid.org/0000-0001-9352-4257Raquel BITTENCOURThttps://orcid.org/0000-0002-8224-2120Marco Antonio Trevizani MARTINShttps://orcid.org/0000-0001-6073-1807Márcio Ajudarte LOPEShttps://orcid.org/0000-0001-6677-0065Vivian Petersen WAGNERhttps://orcid.org/0000-0002-1447-2135Pablo Agustin VARGAShttps://orcid.org/0000-0003-1840-4911Manoela Domingues MARTINShttps://orcid.org/0000-0001-8662-5965Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242023000100240&lng=en&tlng=enCarcinoma, Acinar CellSalivary Gland NeoplasmsRetrospective Studies |
| spellingShingle | Laura Borges KIRSCHNICK Felipe Martins SILVEIRA Lauren Frenzel SCHUCH Ana Carolina Uchoa VASCONCELOS Ana Paula GOMES Jean Nunes dos SANTOS Dandara Andrade SANTANA Felipe Paiva FONSECA Ricardo Alves MESQUITA Elismauro Francisco de MENDONÇA Sebastião Silvério SOUSA-NETO Hélder Antônio Rebelo PONTES Liam ROBINSON Willie van HEERDEN Román CARLOS-BREGNI Elena María José Román TAGER Luan César da SILVA Virgílio Gonzales ZANELLA Luis Fernando RIVERO Raquel BITTENCOURT Marco Antonio Trevizani MARTINS Márcio Ajudarte LOPES Vivian Petersen WAGNER Pablo Agustin VARGAS Manoela Domingues MARTINS Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study Brazilian Oral Research Carcinoma, Acinar Cell Salivary Gland Neoplasms Retrospective Studies |
| title | Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study |
| title_full | Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study |
| title_fullStr | Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study |
| title_full_unstemmed | Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study |
| title_short | Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study |
| title_sort | acinic cell carcinoma of the oral and maxillofacial region an international multicenter study |
| topic | Carcinoma, Acinar Cell Salivary Gland Neoplasms Retrospective Studies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242023000100240&lng=en&tlng=en |
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