Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicus
The present study was designed to know the effect of sertraline and fluoxetine on the reproductive abilities of male rats. The experiment consisted of five groups (each group contains of 5 males), the first (control) group was injected (I.P) with 0.25ml of normal saline, the second group was inject...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2019-05-01
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| Series: | مجلة علوم ذي قار |
| Subjects: | |
| Online Access: | https://www.jsci.utq.edu.iq/index.php/main/article/view/244 |
| _version_ | 1797595910682705920 |
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| author | Zaman Subhi Madlool Satar Abood Faris Ali M. Hussein |
| author_facet | Zaman Subhi Madlool Satar Abood Faris Ali M. Hussein |
| author_sort | Zaman Subhi Madlool |
| collection | DOAJ |
| description | The present study was designed to know the effect of sertraline and fluoxetine on the reproductive abilities of male rats. The experiment consisted of five groups (each group contains of 5 males), the first (control) group was injected (I.P) with 0.25ml of normal saline, the second group was injected with sertraline (10 mg / kg), the third group was injected with sertraline (20 mg / kg), the fourth group was injected with fluoxetine (5 mg / kg) and the fifth group was injected with fluoxetine (10 mg / kg). .The results showed a significant decrease (P?0.05) in the number of sperms and in the level of testosterone hormone and a significant increase (P?0.05) in the percentage of sperm deformities in all treated groups when compared with control group. The histologically examination showed that there was changes in the testis including the dissociation of the connective tissue in second and fifth groups, decrease in the number of spermatgonia, and Leydig cells, bloody congestion in third and fifth groups, hemorrhage and necrosis in forth group. |
| first_indexed | 2024-03-11T02:43:12Z |
| format | Article |
| id | doaj.art-dc3533b212af4fe6be515ced4a55772a |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-11T02:43:12Z |
| publishDate | 2019-05-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-dc3533b212af4fe6be515ced4a55772a2023-11-18T09:29:44ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562019-05-0171Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicusZaman Subhi Madlool0Satar Abood Faris1Ali M. Hussein2College of Education for Pure Science/University of Thi-Qar, IraqCollege of Education for Pure Science/University of Thi-Qar, IraqCollege of Agriculture/University of Sumer, IraqThe present study was designed to know the effect of sertraline and fluoxetine on the reproductive abilities of male rats. The experiment consisted of five groups (each group contains of 5 males), the first (control) group was injected (I.P) with 0.25ml of normal saline, the second group was injected with sertraline (10 mg / kg), the third group was injected with sertraline (20 mg / kg), the fourth group was injected with fluoxetine (5 mg / kg) and the fifth group was injected with fluoxetine (10 mg / kg). .The results showed a significant decrease (P?0.05) in the number of sperms and in the level of testosterone hormone and a significant increase (P?0.05) in the percentage of sperm deformities in all treated groups when compared with control group. The histologically examination showed that there was changes in the testis including the dissociation of the connective tissue in second and fifth groups, decrease in the number of spermatgonia, and Leydig cells, bloody congestion in third and fifth groups, hemorrhage and necrosis in forth group.https://www.jsci.utq.edu.iq/index.php/main/article/view/244FluoxetineSertralineSpermsTestisRats |
| spellingShingle | Zaman Subhi Madlool Satar Abood Faris Ali M. Hussein Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicus مجلة علوم ذي قار Fluoxetine Sertraline Sperms Testis Rats |
| title | Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicus |
| title_full | Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicus |
| title_fullStr | Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicus |
| title_full_unstemmed | Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicus |
| title_short | Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattus norvegicus |
| title_sort | effect of sertraline and fluoxetine on the reproductive abilities of male rats rattus norvegicus |
| topic | Fluoxetine Sertraline Sperms Testis Rats |
| url | https://www.jsci.utq.edu.iq/index.php/main/article/view/244 |
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