Non-Nucleoside Inhibitors Decrease Foot-and-Mouth Disease Virus Replication by Blocking the Viral 3D<sup>pol</sup>

Non-Nucleoside Inhibitors Decrease Foot-and-Mouth Disease Virus Replication by Blocking the Viral 3D<sup>pol</sup>

Foot-and-mouth disease virus (FMDV), an economically important pathogen of cloven-hoofed livestock, is a positive-sense, single-stranded RNA virus classified in the <i>Picornaviridae</i> family. RNA-dependent RNA polymerase (RdRp) of RNA viruses is highly conserved. Compounds that bind t...

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Bibliographic Details
Main Authors: Sirin Theerawatanasirikul, Ploypailin Semkum, Varanya Lueangaramkul, Penpitcha Chankeeree, Nattarat Thangthamniyom, Porntippa Lekcharoensuk
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
foot-and-mouth disease virus (FMDV)
RNA-dependent RNA polymerase (RdRp)
3D polymerase (3D<sup>pol</sup>)
small molecule
virtual screening
antiviral cell-based assay
Online Access:https://www.mdpi.com/1999-4915/15/1/124

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