Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective
Oncolytic viruses have positively impacted cancer immunotherapy over the past 20 years. Both natural and genetically modified viruses have shown promising results in treating various cancers. Various regulatory authorities worldwide have approved four commercial oncolytic viruses, and more are being...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/8/1645 |
| _version_ | 1797583101653680128 |
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| author | Palaniyandi Muthukutty So Young Yoo |
| author_facet | Palaniyandi Muthukutty So Young Yoo |
| author_sort | Palaniyandi Muthukutty |
| collection | DOAJ |
| description | Oncolytic viruses have positively impacted cancer immunotherapy over the past 20 years. Both natural and genetically modified viruses have shown promising results in treating various cancers. Various regulatory authorities worldwide have approved four commercial oncolytic viruses, and more are being developed to overcome this limitation and obtain better anti-tumor responses in clinical trials at various stages. Faster advancements in translating research into the commercialization of cancer immunotherapy and a comprehensive understanding of the modification strategies will widen the current knowledge of future technologies related to the development of oncolytic viruses. In this review, we discuss the strategies of virus engineering and the progress of clinical trials to achieve virotherapeutics. |
| first_indexed | 2024-03-10T23:31:07Z |
| format | Article |
| id | doaj.art-dc3652c44b624dc8ad28493d63d4ea65 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T23:31:07Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-dc3652c44b624dc8ad28493d63d4ea652023-11-19T03:19:39ZengMDPI AGViruses1999-49152023-07-01158164510.3390/v15081645Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy PerspectivePalaniyandi Muthukutty0So Young Yoo1BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of KoreaBIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of KoreaOncolytic viruses have positively impacted cancer immunotherapy over the past 20 years. Both natural and genetically modified viruses have shown promising results in treating various cancers. Various regulatory authorities worldwide have approved four commercial oncolytic viruses, and more are being developed to overcome this limitation and obtain better anti-tumor responses in clinical trials at various stages. Faster advancements in translating research into the commercialization of cancer immunotherapy and a comprehensive understanding of the modification strategies will widen the current knowledge of future technologies related to the development of oncolytic viruses. In this review, we discuss the strategies of virus engineering and the progress of clinical trials to achieve virotherapeutics.https://www.mdpi.com/1999-4915/15/8/1645oncolytic viruscancerimmunotherapyvirotherapyclinical trials |
| spellingShingle | Palaniyandi Muthukutty So Young Yoo Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective Viruses oncolytic virus cancer immunotherapy virotherapy clinical trials |
| title | Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective |
| title_full | Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective |
| title_fullStr | Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective |
| title_full_unstemmed | Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective |
| title_short | Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective |
| title_sort | oncolytic virus engineering and utilizations cancer immunotherapy perspective |
| topic | oncolytic virus cancer immunotherapy virotherapy clinical trials |
| url | https://www.mdpi.com/1999-4915/15/8/1645 |
| work_keys_str_mv | AT palaniyandimuthukutty oncolyticvirusengineeringandutilizationscancerimmunotherapyperspective AT soyoungyoo oncolyticvirusengineeringandutilizationscancerimmunotherapyperspective |