Targeting IRE1α and PERK in the endoplasmic reticulum stress pathway attenuates fatty acid-induced insulin resistance in bovine hepatocytes

Targeting IRE1α and PERK in the endoplasmic reticulum stress pathway attenuates fatty acid-induced insulin resistance in bovine hepatocytes

ABSTRACT: Endoplasmic reticulum (ER) stress can be induced by various stimuli and triggers the unfolded protein response to activate intracellular signaling pathways that are mediated by 3 ER-resident sensors: inositol requiring protein-1α (IRE1α), PKR-like ER kinase (PERK), and activating transcrip...

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Hlavní autoři: Zhiyuan Fang, Wenwen Gao, Qianming Jiang, Juan J. Loor, Chenchen Zhao, Xiliang Du, Min Zhang, Yuxiang Song, Zhe Wang, Guowen Liu, Xinwei Li, Lin Lei
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2022-08-01
Edice:Journal of Dairy Science
Témata:
insulin resistance
fatty acids
endoplasmic reticulum stress
IRE1α
PERK
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0022030222003770

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http://www.sciencedirect.com/science/article/pii/S0022030222003770

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