The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis C
As a rule, chronic hepatitis C is manifested by the development of successive stages of liver fibrosis with the formation of eventually cirrhosis and liver cancer. However, in some patients the fibrosis progresses slowly, while in others there is a rapid formation of cirrhosis, which causes high mor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2019-10-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7653 |
| _version_ | 1818249045174386688 |
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| author | T. I. Bevz D. F. Kyrychenko G. A. Martynyuk |
| author_facet | T. I. Bevz D. F. Kyrychenko G. A. Martynyuk |
| author_sort | T. I. Bevz |
| collection | DOAJ |
| description | As a rule, chronic hepatitis C is manifested by the development of successive stages of liver fibrosis with the formation of eventually cirrhosis and liver cancer. However, in some patients the fibrosis progresses slowly, while in others there is a rapid formation of cirrhosis, which causes high mortality among such patients. According to published data, despite a fairly large number of studies regarding liver cirrhosis in chronic hepatitis C, factors contributing to liver fibrogenesis have not been definitively determined. The available data are quite contradictory. In this article, we review studies have assessed the TLR4 + 3725G/C gene polymorphism as a factor that may influence the rate of fibrotic progression. The research will build new approach for avoiding fast fibrogenesis. |
| first_indexed | 2024-12-12T15:30:15Z |
| format | Article |
| id | doaj.art-dc36c41cd04346959a290579f1142ca3 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-12T15:30:15Z |
| publishDate | 2019-10-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-dc36c41cd04346959a290579f1142ca32022-12-22T00:20:08ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-10-0191032833610.5281/zenodo.35813936718The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis CT. I. Bevz0D. F. Kyrychenko1G. A. Martynyuk2National Pirogov Memorial Medical UniversityNational Pirogov Memorial Medical UniversityCentral city hospitalAs a rule, chronic hepatitis C is manifested by the development of successive stages of liver fibrosis with the formation of eventually cirrhosis and liver cancer. However, in some patients the fibrosis progresses slowly, while in others there is a rapid formation of cirrhosis, which causes high mortality among such patients. According to published data, despite a fairly large number of studies regarding liver cirrhosis in chronic hepatitis C, factors contributing to liver fibrogenesis have not been definitively determined. The available data are quite contradictory. In this article, we review studies have assessed the TLR4 + 3725G/C gene polymorphism as a factor that may influence the rate of fibrotic progression. The research will build new approach for avoiding fast fibrogenesis.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7653hcvchronic hepatitis cliver fibrosiscirrhosistlr4 geneviral load |
| spellingShingle | T. I. Bevz D. F. Kyrychenko G. A. Martynyuk The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis C Journal of Education, Health and Sport hcv chronic hepatitis c liver fibrosis cirrhosis tlr4 gene viral load |
| title | The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis C |
| title_full | The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis C |
| title_fullStr | The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis C |
| title_full_unstemmed | The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis C |
| title_short | The value of polymorphism + 3725G / C TLR4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis C |
| title_sort | value of polymorphism 3725g c tlr4 gene as a marker of liver fibrosis progression in patients with chronic hepatitis c |
| topic | hcv chronic hepatitis c liver fibrosis cirrhosis tlr4 gene viral load |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7653 |
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