HIV-1 Proviral Genome Engineering with CRISPR-Cas9 for Mechanistic Studies

HIV-1 Proviral Genome Engineering with CRISPR-Cas9 for Mechanistic Studies

HIV-1 latency remains a barrier to a functional cure because of the ability of virtually silent yet inducible proviruses within reservoir cells to transcriptionally reactivate upon cell stimulation. HIV-1 reactivation occurs through the sequential action of host transcription factors (TFs) during th...

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Bibliographic Details
Main Authors: Usman Hyder, Ashutosh Shukla, Ashwini Challa, Iván D’Orso
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Viruses
Subjects:
HIV-1
Tat
viruses
transcription
CRISPR
Cas9
Online Access:https://www.mdpi.com/1999-4915/16/2/287

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