The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosis
miRNAs are involved in various vital processes, including cell growth, development, apoptosis, cellular differentiation, and pathological cellular activities. Circulating miRNAs can be detected in various body fluids including serum, plasma, saliva, and urine. It is worth mentioning that miRNAs rema...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1281567/full |
| _version_ | 1797391182094925824 |
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| author | Asieh Emami Nejad Seyed Mostafa Mostafavi Zadeh Seyed Mostafa Mostafavi Zadeh Hamid Nickho Ali Sadoogh Abbasian Azim Forouzan Mojtaba Ahmadlou Reza Nedaeinia Saham Shaverdi Mostafa Manian Mostafa Manian |
| author_facet | Asieh Emami Nejad Seyed Mostafa Mostafavi Zadeh Seyed Mostafa Mostafavi Zadeh Hamid Nickho Ali Sadoogh Abbasian Azim Forouzan Mojtaba Ahmadlou Reza Nedaeinia Saham Shaverdi Mostafa Manian Mostafa Manian |
| author_sort | Asieh Emami Nejad |
| collection | DOAJ |
| description | miRNAs are involved in various vital processes, including cell growth, development, apoptosis, cellular differentiation, and pathological cellular activities. Circulating miRNAs can be detected in various body fluids including serum, plasma, saliva, and urine. It is worth mentioning that miRNAs remain stable in the circulation in biological fluids and are released from membrane-bound vesicles called exosomes, which protect them from RNase activity. It has been shown that miRNAs regulate blood-brain barrier integrity by targeting both tight junction and adherens junction molecules and can also influence the expression of inflammatory cytokines. Some recent studies have examined the impact of certain commonly used drugs in Multiple Sclerosis on miRNA levels. In this review, we will focus on the recent findings on the role of miRNAs in multiple sclerosis, including their role in the cause of MS and molecular mechanisms of the disease, utilizing miRNAs as diagnostic and clinical biomarkers, using miRNAs as a therapeutic modality or target for Multiple Sclerosis and drug responses in patients, elucidating their importance as prognosticators of disease progression, and highlighting their potential as a future treatment for MS. |
| first_indexed | 2024-03-08T23:29:16Z |
| format | Article |
| id | doaj.art-dc3c8e9e5b4a47f4a34a75674b7127ce |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T23:29:16Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dc3c8e9e5b4a47f4a34a75674b7127ce2023-12-14T16:54:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.12815671281567The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosisAsieh Emami Nejad0Seyed Mostafa Mostafavi Zadeh1Seyed Mostafa Mostafavi Zadeh2Hamid Nickho3Ali Sadoogh Abbasian4Azim Forouzan5Mojtaba Ahmadlou6Reza Nedaeinia7Saham Shaverdi8Mostafa Manian9Mostafa Manian10Department of Biology, Payame Noor University (PNU), Tehran, IranDepartment of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, IranOncopathology Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, School of Medicine, Amiralmomenin Hospital, Arak University of Medical Sciences, Arak, IranDepartment of Internal Medicine, School of Medicine, Amiralmomenin Hospital, Arak University of Medical Sciences, Arak, IranDepartment of Biostatistics, School of Medicine, Arak University of Medical Sciences, Arak, IranPediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Biology, Payame Noor University (PNU), Tehran, IranDepartment of Medical Laboratory Science, Faculty of Medicine, Islamic Azad University, Kermanshah, IranNeurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranmiRNAs are involved in various vital processes, including cell growth, development, apoptosis, cellular differentiation, and pathological cellular activities. Circulating miRNAs can be detected in various body fluids including serum, plasma, saliva, and urine. It is worth mentioning that miRNAs remain stable in the circulation in biological fluids and are released from membrane-bound vesicles called exosomes, which protect them from RNase activity. It has been shown that miRNAs regulate blood-brain barrier integrity by targeting both tight junction and adherens junction molecules and can also influence the expression of inflammatory cytokines. Some recent studies have examined the impact of certain commonly used drugs in Multiple Sclerosis on miRNA levels. In this review, we will focus on the recent findings on the role of miRNAs in multiple sclerosis, including their role in the cause of MS and molecular mechanisms of the disease, utilizing miRNAs as diagnostic and clinical biomarkers, using miRNAs as a therapeutic modality or target for Multiple Sclerosis and drug responses in patients, elucidating their importance as prognosticators of disease progression, and highlighting their potential as a future treatment for MS.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1281567/fullmiRNAsautoimmunemultiple sclerosisexosomestherapeutic advances |
| spellingShingle | Asieh Emami Nejad Seyed Mostafa Mostafavi Zadeh Seyed Mostafa Mostafavi Zadeh Hamid Nickho Ali Sadoogh Abbasian Azim Forouzan Mojtaba Ahmadlou Reza Nedaeinia Saham Shaverdi Mostafa Manian Mostafa Manian The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosis Frontiers in Immunology miRNAs autoimmune multiple sclerosis exosomes therapeutic advances |
| title | The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosis |
| title_full | The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosis |
| title_fullStr | The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosis |
| title_full_unstemmed | The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosis |
| title_short | The role of microRNAs involved in the disorder of blood–brain barrier in the pathogenesis of multiple sclerosis |
| title_sort | role of micrornas involved in the disorder of blood brain barrier in the pathogenesis of multiple sclerosis |
| topic | miRNAs autoimmune multiple sclerosis exosomes therapeutic advances |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1281567/full |
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