Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China
BackgroundsThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global threat since 2020. The emergence of the Omicron variant in 2021, which replaced Delta as the dominant variant of concern, has had a significant adverse...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1189969/full |
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| author | Biaofeng Zhou Yi Sun Haiyan Mao Lingxuan Su Yihan Lou Hao Yan Wenwu Yao Honghu Chen Yanjun Zhang |
| author_facet | Biaofeng Zhou Yi Sun Haiyan Mao Lingxuan Su Yihan Lou Hao Yan Wenwu Yao Honghu Chen Yanjun Zhang |
| author_sort | Biaofeng Zhou |
| collection | DOAJ |
| description | BackgroundsThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global threat since 2020. The emergence of the Omicron variant in 2021, which replaced Delta as the dominant variant of concern, has had a significant adverse impact on the global economy and public health. During this period, Zhejiang Province implemented dynamic zeroing and focused on preventing imported cases. This study aimed to gain clear insight into the characteristics of imported COVID-19 cases in Zhejiang Province.MethodsWe conducted a systematic molecular epidemiological analysis of 146 imported cases between July 2021 and November 2022 in Zhejiang Province. Virus samples with cycle threshold (Ct) value less than 32 were performed next generation sequencing. Basing the whole genome sequence obtained after quality control and assembly of reads, the whole genome variation map and phylogenetic tree were constructed and further analyzed.ResultsOur study identified critical months and populations for surveillance, profiled the variation of various lineages, determined the evolutionary relationships among various lineages of SARS-CoV-2, and compared the results in Zhejiang with those obtained worldwide during this period.ConclusionThe continuous molecular epidemiological surveillance of imported cases of COVID-19 in Zhejiang Province during 2021 to 2022 is consistent with the global epidemic trend. |
| first_indexed | 2024-03-13T03:55:20Z |
| format | Article |
| id | doaj.art-dc3eae2652024cbdaf8f2c380b26ed9a |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-13T03:55:20Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-dc3eae2652024cbdaf8f2c380b26ed9a2023-06-22T06:44:14ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-06-011110.3389/fpubh.2023.11899691189969Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, ChinaBiaofeng ZhouYi SunHaiyan MaoLingxuan SuYihan LouHao YanWenwu YaoHonghu ChenYanjun ZhangBackgroundsThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global threat since 2020. The emergence of the Omicron variant in 2021, which replaced Delta as the dominant variant of concern, has had a significant adverse impact on the global economy and public health. During this period, Zhejiang Province implemented dynamic zeroing and focused on preventing imported cases. This study aimed to gain clear insight into the characteristics of imported COVID-19 cases in Zhejiang Province.MethodsWe conducted a systematic molecular epidemiological analysis of 146 imported cases between July 2021 and November 2022 in Zhejiang Province. Virus samples with cycle threshold (Ct) value less than 32 were performed next generation sequencing. Basing the whole genome sequence obtained after quality control and assembly of reads, the whole genome variation map and phylogenetic tree were constructed and further analyzed.ResultsOur study identified critical months and populations for surveillance, profiled the variation of various lineages, determined the evolutionary relationships among various lineages of SARS-CoV-2, and compared the results in Zhejiang with those obtained worldwide during this period.ConclusionThe continuous molecular epidemiological surveillance of imported cases of COVID-19 in Zhejiang Province during 2021 to 2022 is consistent with the global epidemic trend.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1189969/fullSARS-CoV-2genetic variationimported caseswhole genome sequencingphylogenetic analysis |
| spellingShingle | Biaofeng Zhou Yi Sun Haiyan Mao Lingxuan Su Yihan Lou Hao Yan Wenwu Yao Honghu Chen Yanjun Zhang Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China Frontiers in Public Health SARS-CoV-2 genetic variation imported cases whole genome sequencing phylogenetic analysis |
| title | Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China |
| title_full | Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China |
| title_fullStr | Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China |
| title_full_unstemmed | Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China |
| title_short | Molecular epidemiological characteristics of SARS-CoV-2 in imported cases from 2021 to 2022 in Zhejiang Province, China |
| title_sort | molecular epidemiological characteristics of sars cov 2 in imported cases from 2021 to 2022 in zhejiang province china |
| topic | SARS-CoV-2 genetic variation imported cases whole genome sequencing phylogenetic analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1189969/full |
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