Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression
Abstract Background With increasing axial length and myopia progression, the micro-structure of the retina and choroid gradually changes. Our study describes the longitudinal changes in retinal and choroidal thickness in school-aged children with myopia and explores the relationship between changes...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Eye and Vision |
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| Online Access: | https://doi.org/10.1186/s40662-022-00276-4 |
| _version_ | 1818085242255179776 |
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| author | Meiping Xu Xinping Yu Minghui Wan Kemi Feng Junxiao Zhang Meixiao Shen Björn Drobe Hao Chen Jia Qu Jinhua Bao |
| author_facet | Meiping Xu Xinping Yu Minghui Wan Kemi Feng Junxiao Zhang Meixiao Shen Björn Drobe Hao Chen Jia Qu Jinhua Bao |
| author_sort | Meiping Xu |
| collection | DOAJ |
| description | Abstract Background With increasing axial length and myopia progression, the micro-structure of the retina and choroid gradually changes. Our study describes the longitudinal changes in retinal and choroidal thickness in school-aged children with myopia and explores the relationship between changes in choroidal thickness and myopia progression. Methods An exploratory analysis of a randomized trial was performed. Children (n = 168, aged 7 to 12 years) with myopia from − 0.75 dioptre (D) to − 4.00 D were enrolled in this prospective longitudinal study. Cycloplegic refraction, axial length (AL), retinal and choroidal thicknesses were measured at baseline and at 1- and 2-year follow-ups. “Rapid progression myopia” was defined as increasing in myopia > 1.00 D and “stable progression myopia” was ≤ 1.00 D during the 2-year follow-up. Factors affecting the changes in choroidal thickness were analysed using linear mixed models. Results AL significantly increased by 0.67 ± 0.24 mm with a myopic shift of − 1.50 ± 0.64 D over the 2 years. The overall retinal thickness increased from 251.12 ± 15.91 µm at baseline to 253.47 ± 15.74 µm at the 2-year follow-up (F = 23.785, P < 0.001). The subfoveal choroidal thickness decreased from 231.03 ± 54.04 µm at baseline to 206.53 ± 59.71 µm at the 2-year follow-up (F = 73.358, P < 0.001). Choroidal thinning was significantly associated with AL elongation (β = − 43.579 μm/mm, P = 0.002) and sex (β = − 17.258, P = 0.001). Choroidal thickness continued to decrease in subjects with rapid progression (F = 92.06, P < 0.001) but not in those with steady progression (F = 2.23, P = 0.119). Conclusion Significant choroidal thinning was observed and was associated with rapid progression and sex. These findings indicate a need to understand the role of the choroid in eye growth and myopia development. Synopsis/Precis The macular choroidal thickness of myopic children is relevant to different degrees of myopic progression in this 2-year longitudinal study. These findings suggest that control of choroidal thickness might work to regulate human ocular growth. Trial registration Chinese Clinical Trial Register (ChiCTR): ChiCTR-INR-16007722 |
| first_indexed | 2024-12-10T20:06:40Z |
| format | Article |
| id | doaj.art-dc3f5a4837414d61961df946fccc021f |
| institution | Directory Open Access Journal |
| issn | 2326-0254 |
| language | English |
| last_indexed | 2024-12-10T20:06:40Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Eye and Vision |
| spelling | doaj.art-dc3f5a4837414d61961df946fccc021f2022-12-22T01:35:23ZengBMCEye and Vision2326-02542022-02-019111010.1186/s40662-022-00276-4Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progressionMeiping Xu0Xinping Yu1Minghui Wan2Kemi Feng3Junxiao Zhang4Meixiao Shen5Björn Drobe6Hao Chen7Jia Qu8Jinhua Bao9Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityWEIRC, WMU-Essilor International Research CentreEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical UniversityAbstract Background With increasing axial length and myopia progression, the micro-structure of the retina and choroid gradually changes. Our study describes the longitudinal changes in retinal and choroidal thickness in school-aged children with myopia and explores the relationship between changes in choroidal thickness and myopia progression. Methods An exploratory analysis of a randomized trial was performed. Children (n = 168, aged 7 to 12 years) with myopia from − 0.75 dioptre (D) to − 4.00 D were enrolled in this prospective longitudinal study. Cycloplegic refraction, axial length (AL), retinal and choroidal thicknesses were measured at baseline and at 1- and 2-year follow-ups. “Rapid progression myopia” was defined as increasing in myopia > 1.00 D and “stable progression myopia” was ≤ 1.00 D during the 2-year follow-up. Factors affecting the changes in choroidal thickness were analysed using linear mixed models. Results AL significantly increased by 0.67 ± 0.24 mm with a myopic shift of − 1.50 ± 0.64 D over the 2 years. The overall retinal thickness increased from 251.12 ± 15.91 µm at baseline to 253.47 ± 15.74 µm at the 2-year follow-up (F = 23.785, P < 0.001). The subfoveal choroidal thickness decreased from 231.03 ± 54.04 µm at baseline to 206.53 ± 59.71 µm at the 2-year follow-up (F = 73.358, P < 0.001). Choroidal thinning was significantly associated with AL elongation (β = − 43.579 μm/mm, P = 0.002) and sex (β = − 17.258, P = 0.001). Choroidal thickness continued to decrease in subjects with rapid progression (F = 92.06, P < 0.001) but not in those with steady progression (F = 2.23, P = 0.119). Conclusion Significant choroidal thinning was observed and was associated with rapid progression and sex. These findings indicate a need to understand the role of the choroid in eye growth and myopia development. Synopsis/Precis The macular choroidal thickness of myopic children is relevant to different degrees of myopic progression in this 2-year longitudinal study. These findings suggest that control of choroidal thickness might work to regulate human ocular growth. Trial registration Chinese Clinical Trial Register (ChiCTR): ChiCTR-INR-16007722https://doi.org/10.1186/s40662-022-00276-4Axial lengthChoroidal thicknessChildrenMyopiaSpectral-domain optical coherence tomography |
| spellingShingle | Meiping Xu Xinping Yu Minghui Wan Kemi Feng Junxiao Zhang Meixiao Shen Björn Drobe Hao Chen Jia Qu Jinhua Bao Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression Eye and Vision Axial length Choroidal thickness Children Myopia Spectral-domain optical coherence tomography |
| title | Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression |
| title_full | Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression |
| title_fullStr | Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression |
| title_full_unstemmed | Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression |
| title_short | Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression |
| title_sort | two year longitudinal change in choroidal and retinal thickness in school aged myopic children exploratory analysis of clinical trials for myopia progression |
| topic | Axial length Choroidal thickness Children Myopia Spectral-domain optical coherence tomography |
| url | https://doi.org/10.1186/s40662-022-00276-4 |
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