Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-06-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e057460.full |
| _version_ | 1811241734050414592 |
|---|---|
| author | Eva Skovlund Rune Haaverstad Henrik Zetterberg Jorunn L Helbostad Rolf Busund Johan Raeder Theis Tønnessen Torgeir Bruun Wyller Melanie R Simpson Nils Kristian Skjærvold Bjørn Erik Neerland Svein Aslak Landsverk Ieva Martinaityte Hilde Margrethe Norum Geir Selbaek Elisabeth Skaar Arjen JC Slooter Øyvind Sverre Svendsen Alexander Wahba |
| author_facet | Eva Skovlund Rune Haaverstad Henrik Zetterberg Jorunn L Helbostad Rolf Busund Johan Raeder Theis Tønnessen Torgeir Bruun Wyller Melanie R Simpson Nils Kristian Skjærvold Bjørn Erik Neerland Svein Aslak Landsverk Ieva Martinaityte Hilde Margrethe Norum Geir Selbaek Elisabeth Skaar Arjen JC Slooter Øyvind Sverre Svendsen Alexander Wahba |
| author_sort | Eva Skovlund |
| collection | DOAJ |
| first_indexed | 2024-04-12T13:40:39Z |
| format | Article |
| id | doaj.art-dc402255825049c9a5e70d0adb99cc36 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-12T13:40:39Z |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-dc402255825049c9a5e70d0adb99cc362022-12-22T03:30:51ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-057460Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trialEva Skovlund0Rune Haaverstad1Henrik Zetterberg2Jorunn L Helbostad3Rolf Busund4Johan Raeder5Theis Tønnessen6Torgeir Bruun Wyller7Melanie R Simpson8Nils Kristian Skjærvold9Bjørn Erik Neerland10Svein Aslak Landsverk11Ieva Martinaityte12Hilde Margrethe Norum13Geir Selbaek14Elisabeth Skaar15Arjen JC Slooter16Øyvind Sverre Svendsen17Alexander Wahba18Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Trondheim, Trøndelag, NorwayDepartment of Heart Disease, Haukeland University Hospital, Bergen, NorwayDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UKDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, NorwayInstitute of Clinical Medicine, The Arctic University of Norway, UiT, Tromsø, NorwayDepartment of Anaesthesiology, Oslo University Hospital, Oslo, Norway6 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway4 Oslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo, Oslo, NorwayDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Anesthesiology and Intensive Care Medicine, St. Olav`s University Hospital, Trondheim, NorwayDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Anaesthesiology, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, UiT The Artic University of Norway, Tromsø, NorwayDepartment of Anaesthesiology, Oslo University Hospital, Oslo, NorwayDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Heart Disease, Haukeland University Hospital, Bergen, NorwayDepartment of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, The NetherlandsDepartment of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, NorwayDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norwayhttps://bmjopen.bmj.com/content/12/6/e057460.full |
| spellingShingle | Eva Skovlund Rune Haaverstad Henrik Zetterberg Jorunn L Helbostad Rolf Busund Johan Raeder Theis Tønnessen Torgeir Bruun Wyller Melanie R Simpson Nils Kristian Skjærvold Bjørn Erik Neerland Svein Aslak Landsverk Ieva Martinaityte Hilde Margrethe Norum Geir Selbaek Elisabeth Skaar Arjen JC Slooter Øyvind Sverre Svendsen Alexander Wahba Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial BMJ Open |
| title | Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial |
| title_full | Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial |
| title_fullStr | Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial |
| title_full_unstemmed | Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial |
| title_short | Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial |
| title_sort | alpha 2 adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery alpha2prevent protocol for a multicentre randomised controlled trial |
| url | https://bmjopen.bmj.com/content/12/6/e057460.full |
| work_keys_str_mv | AT evaskovlund alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT runehaaverstad alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT henrikzetterberg alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT jorunnlhelbostad alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT rolfbusund alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT johanraeder alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT theistønnessen alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT torgeirbruunwyller alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT melaniersimpson alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT nilskristianskjærvold alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT bjørnerikneerland alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT sveinaslaklandsverk alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT ievamartinaityte alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT hildemargrethenorum alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT geirselbaek alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT elisabethskaar alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT arjenjcslooter alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT øyvindsverresvendsen alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial AT alexanderwahba alpha2adrenergicreceptoragonistsforthepreventionofdeliriumandcognitivedeclineafteropenheartsurgeryalpha2preventprotocolforamulticentrerandomisedcontrolledtrial |