Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial

Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial

Bibliographic Details
Main Authors:	Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2022-06-01
Series:	BMJ Open
Online Access:	https://bmjopen.bmj.com/content/12/6/e057460.full

Similar Items

Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses
by: Bjørn Erik Neerland, et al.
Published: (2019-01-01)

Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour
by: Uzma Urooj, et al.
Published: (2023-03-01)

Preventative effects of alpha-naphtho flavone in vascular dementia
by: Narahari Rishitha, et al.
Published: (2020-01-01)

The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses
by: Karen Roksund Hov, et al.
Published: (2018-06-01)

Screening of Alpha-Glucosidase and Alpha-Amylase Inhibitors in the Descurainia Sophia Flower by Molecular Docking to Prevention the Progression of Diabetes
by: Morteza Sadeghi
Published: (2020-08-01)

Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson’s Disease
by: Michael Jewett, et al.
Published: (2018-04-01)

Role of 5-alpha reductase inhibitors in the prevention of prostate cancer
by: Bhupendra P Singh, et al.
Published: (2011-01-01)

Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study.
by: Bjørn Erik Neerland, et al.
Published: (2017-01-01)

Alpha B-Crystallin in Muscle Disease Prevention: The Role of Physical Activity
by: Ivan Dimauro, et al.
Published: (2022-02-01)

The preventive effect of Chlorhexidine mouthwash on alpha-hemolytic Streptococci and Staphylococcus aureus
by: Mohammad-Hassan Akhavan Karbassi, et al.
Published: (2019-03-01)

Assessing the efficacy of TNF‐alpha inhibitors in preventing emergency and emergent colectomies
by: Ruben Rajan, et al.
Published: (2020-04-01)

Environmental Enrichment Prevents Transcriptional Disturbances Induced by Alpha-Synuclein Overexpression
by: Zinah Wassouf, et al.
Published: (2018-04-01)

The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial
by: Wyller Torgeir, et al.
Published: (2012-07-01)

The economic burden of TNF&alpha; inhibitors and other biologic treatments in Norway
by: Jan Norum, et al.
Published: (2011-03-01)

Preventive classes for elderly living at home: Who participates and what gives motivation to participate?
by: Randi Granbo, et al.
Published: (2015-09-01)

Alpha-glucosidase inhibitors prevent the assembly and induce a reduction of HCV infectivity
by: Chapel, C, et al.
Published: (2006)

Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention
by: Natasha Bobrowski-Khoury, et al.
Published: (2021-07-01)

Diagnosing alpha-1 antitrypsin deficiency: does it prevent or improve the course of COPD?
by: Irma Godoy

Alpha-1 antitrypsin prevents the development of preeclampsia through suppression of oxidative stress
by: Yaling eFeng, et al.
Published: (2016-05-01)

Gait, physical function, and physical activity in three groups of home-dwelling older adults with different severity of cognitive impairment – a cross-sectional study
by: Kristin Taraldsen, et al.
Published: (2021-12-01)

Conversion of 7alpha-hydroxycholesterol and 7alpha-hydroxy-beta-sitosterol to 3alpha, 7alpha-dihydroxy- and 3alpha, 7alpha, 12alpha-trihydroxy-5beta-steroids in vitro.
by: L Aringer
Published: (1975-11-01)

Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha.
by: Fekade, D, et al.
Published: (1996)

Influence of alpha-glutamil-tryptophan on the background and induced activity of factors of adaptive immunity for prevention
by: A. A. Ruleva, et al.
Published: (2024-01-01)

Hydroxycinnamic Acid Derivatives from Coffee Extracts Prevent Amyloid Transformation of Alpha-Synuclein
by: Maria Medvedeva, et al.
Published: (2022-09-01)

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
by: Rita Rosado-Ramos, et al.
Published: (2023-04-01)

Preventing synaptic deficits in Alzheimer’s disease by inhibiting tumor necrosis factor alpha signaling
by: Chelsea Cavanagh, et al.
Published: (2018-06-01)

Recombinant human interferon alpha 2b prevents and reverses experimental pulmonary hypertension.
by: Eileen M Bauer, et al.
Published: (2014-01-01)

Prevention of Radicalism for Alpha Generations in Raudhatul Athfal by Fatayat NU Cilacap Central Java
by: Novan Ardy Wiyani
Published: (2019-11-01)

Quality of life of family carers of persons with young-onset dementia: A Nordic two-year observational multicenter study.
by: Lara Hvidsten, et al.
Published: (2019-01-01)

Alpha-santalol, a derivative of sandalwood oil prevents development of prostate cancer in TRAMP mice
by: Ajay Bommareddy, et al.
Published: (2024-02-01)

The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice
by: Daniely V. S. Costa, et al.
Published: (2020-11-01)

An Oral Selective Alpha-1A AdrenergicÂ Receptor Agonist Prevents Doxorubicin Cardiotoxicity
by: Ju Youn Beak, PhD, et al.
Published: (2017-02-01)

Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats
by: Rakesh Sahu, et al.
Published: (2022-01-01)

An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.
by: Megan D Montgomery, et al.
Published: (2017-01-01)

Flaxseed Prevents Interferon-alpha Induced Depressive Behavior in Mice: the α-Linolenic Acid is Essential
by: Azadeh Mesripour*, et al.
Published: (2021-01-01)

Catalpol Inhibits Macrophage Polarization and Prevents Postmenopausal Atherosclerosis Through Regulating Estrogen Receptor Alpha
by: Qi Chen, et al.
Published: (2021-04-01)

Calcium: alpha-synuclein interactions in alpha-synucleinopathies
by: Alexandre N. Rcom-H’cheo-Gauthier1, et al.
Published: (2016-12-01)

On the $ A_{\alpha^-} $-spectra of graphs and the relation between $ A_{\alpha} $- and $ A_{\alpha^-} $-spectra
by: Wafaa Fakieh, et al.
Published: (2024-01-01)

Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver.
by: K Prydz, et al.
Published: (1988-08-01)

Longitudinal trajectories of functional recovery after hip fracture.
by: Shams Dakhil, et al.
Published: (2023-01-01)