Ovalbumin-specific CD4+ and CD8+ T cells contribute to different susceptibility for Theiler’s murine encephalomyelitis virus persistence

Ovalbumin-specific CD4+ and CD8+ T cells contribute to different susceptibility for Theiler’s murine encephalomyelitis virus persistence

Theiler’s murine encephalomyelitis virus (TMEV) is the causative agent of TMEV-induced demyelinating disease (TMEV-IDD); a well-established animal model for the chronic progressive form of human multiple sclerosis (MS). In susceptible mice with an inadequate immune response, TMEV-IDD is triggered by...

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Bibliographic Details
Main Authors: Rouven Wannemacher, Anna Reiß, Karl Rohn, Fred Lühder, Alexander Flügel, Wolfgang Baumgärtner, Kirsten Hülskötter
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
central nervous system
OT mice
Theiler’s murine encephalomyelitis virus (TMEV)
OVA-specific CD8+ T cells
OVA-specific CD4+ T cells
microgliosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194842/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194842/full

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