Evaluation of Pharmacokinetic Feasibility of Febuxostat/L-pyroglutamic Acid Cocrystals in Rats and Mice

Evaluation of Pharmacokinetic Feasibility of Febuxostat/L-pyroglutamic Acid Cocrystals in Rats and Mice

Febuxostat (FBX), a selective xanthine oxidase inhibitor, belongs to BCS class II, showing low solubility and high permeability with a moderate <i>F</i> value (<49%). Recently, FBX/L-pyroglutamic acid cocrystal (FBX-PG) was developed with an improving 4-fold increase of FBX solubility...

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Bibliographic Details
Main Authors: Jeong-Eun Yu, Byoung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung, Young Hee Choi
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
febuxostat
FBX/L-pyroglutamic acid cocrystals
pharmacokinetics
bioavailability
Online Access:https://www.mdpi.com/1999-4923/15/8/2167

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