Molecular and clinical characterization of PTRF in glioma via 1,022 samples
Abstract Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequen...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-023-11001-2 |
| _version_ | 1827922968248844288 |
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| author | Si Sun Changlin Yang Kuanyu Wang Ruoyu Huang Ke-nan Zhang Yanwei Liu Zhi Cao Zheng Zhao Tao Jiang |
| author_facet | Si Sun Changlin Yang Kuanyu Wang Ruoyu Huang Ke-nan Zhang Yanwei Liu Zhi Cao Zheng Zhao Tao Jiang |
| author_sort | Si Sun |
| collection | DOAJ |
| description | Abstract Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequencing (RNA-seq) data (n = 1022 cases) and whole-exome sequencing (WES) data (n = 286 cases) were used to characterize the PTRF expression features. Gene ontology (GO) functional enrichment analysis was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed distinct genomic alteration. Furthermore, GO functional enrichment analysis suggested that PTRF expression was associated with cell migration and angiogenesis, particularly during an immune response. Survival analysis confirmed that a high expression of PTRF is associated with a poor prognosis. In summary, PTRF may be a valuable factor for the diagnosis and treatment target of glioma. |
| first_indexed | 2024-03-13T04:49:55Z |
| format | Article |
| id | doaj.art-dc42fc63beea4760a4a0286ebd21bf45 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-13T04:49:55Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-dc42fc63beea4760a4a0286ebd21bf452023-06-18T11:16:39ZengBMCBMC Cancer1471-24072023-06-0123111310.1186/s12885-023-11001-2Molecular and clinical characterization of PTRF in glioma via 1,022 samplesSi Sun0Changlin Yang1Kuanyu Wang2Ruoyu Huang3Ke-nan Zhang4Yanwei Liu5Zhi Cao6Zheng Zhao7Tao Jiang8Beijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityDepartment of Radiotherapy, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, The Fourth Affiliated Hospital of China Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityAbstract Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequencing (RNA-seq) data (n = 1022 cases) and whole-exome sequencing (WES) data (n = 286 cases) were used to characterize the PTRF expression features. Gene ontology (GO) functional enrichment analysis was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed distinct genomic alteration. Furthermore, GO functional enrichment analysis suggested that PTRF expression was associated with cell migration and angiogenesis, particularly during an immune response. Survival analysis confirmed that a high expression of PTRF is associated with a poor prognosis. In summary, PTRF may be a valuable factor for the diagnosis and treatment target of glioma.https://doi.org/10.1186/s12885-023-11001-2PTRFGliomaPrognosisImmune response |
| spellingShingle | Si Sun Changlin Yang Kuanyu Wang Ruoyu Huang Ke-nan Zhang Yanwei Liu Zhi Cao Zheng Zhao Tao Jiang Molecular and clinical characterization of PTRF in glioma via 1,022 samples BMC Cancer PTRF Glioma Prognosis Immune response |
| title | Molecular and clinical characterization of PTRF in glioma via 1,022 samples |
| title_full | Molecular and clinical characterization of PTRF in glioma via 1,022 samples |
| title_fullStr | Molecular and clinical characterization of PTRF in glioma via 1,022 samples |
| title_full_unstemmed | Molecular and clinical characterization of PTRF in glioma via 1,022 samples |
| title_short | Molecular and clinical characterization of PTRF in glioma via 1,022 samples |
| title_sort | molecular and clinical characterization of ptrf in glioma via 1 022 samples |
| topic | PTRF Glioma Prognosis Immune response |
| url | https://doi.org/10.1186/s12885-023-11001-2 |
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