Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scores
BackgroundHepatolenticular degeneration [Wilson disease (WD)] is an autosomal recessive metabolic disease characterized by copper metabolism disorder. Cognitive impairment is a key neuropsychiatric symptom of WD. At present, there is no effective treatment for WD-related cognitive impairment.Methods...
| Главные авторы: | , , , |
|---|---|
| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Frontiers Media S.A.
2024-04-01
|
| Серии: | Frontiers in Neuroscience |
| Предметы: | |
| Online-ссылка: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1375234/full |
| _version_ | 1827288862377902080 |
|---|---|
| author | Hong Chen Xie Wang Juan Zhang Daojun Xie |
| author_facet | Hong Chen Xie Wang Juan Zhang Daojun Xie |
| author_sort | Hong Chen |
| collection | DOAJ |
| description | BackgroundHepatolenticular degeneration [Wilson disease (WD)] is an autosomal recessive metabolic disease characterized by copper metabolism disorder. Cognitive impairment is a key neuropsychiatric symptom of WD. At present, there is no effective treatment for WD-related cognitive impairment.MethodsIn this study, high-frequency repetitive transcranial magnetic stimulation (rTMS) was used to treat WD-related cognitive impairment, and inverse probability weighting of propensity scores was used to correct for confounding factors. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Auditory Verbal Learning Test (AVLT), Boston Naming Test (BNT), Clock Drawing Test (CDT) and Trail Making Test (TMT) were used to evaluate overall cognition and specific cognitive domains.ResultsThe MMSE, MoCA and CDT scores after treatment were significantly different from those before treatment (MMSE: before adjustment: OR = 1.404, 95% CI: 1.271–1.537; after adjustment: OR = 1.381, 95% CI: 1.265–1.497, p < 0.001; MoCA: before adjustment: OR = 1.306, 95% CI: 1.122–1.490; after adjustment: OR = 1.286, 95% CI: 1.104; AVLT: OR = 1.161, 95% CI: 1.074–1.248; after adjustment: OR = 1.145, 95% CI: 1.068–1.222, p < 0.05; CDT: OR = 1.524, 95% CI: 1.303–1.745; after adjustment: OR = 1.518, 95% CI: 1.294–1.742, p < 0.001). The BNT and TMT scores after adjustment were not significantly different from those before adjustment (BNT: before adjustment: OR = 1.048, 95% CI: 0.877–1.219; after adjustment: OR = 1.026, 95% CI: 0.863–1.189, p > 0.05; TMT: before adjustment: OR = 0.816, 95% CI: 1.122–1.490; after adjustment: OR = 0.791, 95% CI: 0.406–1.176, p > 0.05).ConclusionHigh-frequency rTMS can effectively improve cognitive impairment, especially memory and visuospatial ability, in WD patients. The incidence of side effects is low, and the safety is good. |
| first_indexed | 2024-04-24T11:39:56Z |
| format | Article |
| id | doaj.art-dc43918b679140b6abeab3c46d55a91b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-24T11:39:56Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-dc43918b679140b6abeab3c46d55a91b2024-04-10T04:23:06ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-04-011810.3389/fnins.2024.13752341375234Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scoresHong Chen0Xie Wang1Juan Zhang2Daojun Xie3The First Clinical Mdical College of Anhui University of Chinese Medicine, Hefei, ChinaThe First Clinical Mdical College of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, ChinaBackgroundHepatolenticular degeneration [Wilson disease (WD)] is an autosomal recessive metabolic disease characterized by copper metabolism disorder. Cognitive impairment is a key neuropsychiatric symptom of WD. At present, there is no effective treatment for WD-related cognitive impairment.MethodsIn this study, high-frequency repetitive transcranial magnetic stimulation (rTMS) was used to treat WD-related cognitive impairment, and inverse probability weighting of propensity scores was used to correct for confounding factors. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Auditory Verbal Learning Test (AVLT), Boston Naming Test (BNT), Clock Drawing Test (CDT) and Trail Making Test (TMT) were used to evaluate overall cognition and specific cognitive domains.ResultsThe MMSE, MoCA and CDT scores after treatment were significantly different from those before treatment (MMSE: before adjustment: OR = 1.404, 95% CI: 1.271–1.537; after adjustment: OR = 1.381, 95% CI: 1.265–1.497, p < 0.001; MoCA: before adjustment: OR = 1.306, 95% CI: 1.122–1.490; after adjustment: OR = 1.286, 95% CI: 1.104; AVLT: OR = 1.161, 95% CI: 1.074–1.248; after adjustment: OR = 1.145, 95% CI: 1.068–1.222, p < 0.05; CDT: OR = 1.524, 95% CI: 1.303–1.745; after adjustment: OR = 1.518, 95% CI: 1.294–1.742, p < 0.001). The BNT and TMT scores after adjustment were not significantly different from those before adjustment (BNT: before adjustment: OR = 1.048, 95% CI: 0.877–1.219; after adjustment: OR = 1.026, 95% CI: 0.863–1.189, p > 0.05; TMT: before adjustment: OR = 0.816, 95% CI: 1.122–1.490; after adjustment: OR = 0.791, 95% CI: 0.406–1.176, p > 0.05).ConclusionHigh-frequency rTMS can effectively improve cognitive impairment, especially memory and visuospatial ability, in WD patients. The incidence of side effects is low, and the safety is good.https://www.frontiersin.org/articles/10.3389/fnins.2024.1375234/fullhigh frequency repetitive transcranial magnetic stimulationpropensity scoreinverse probability weightingWilson diseasecognitive impairment |
| spellingShingle | Hong Chen Xie Wang Juan Zhang Daojun Xie Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scores Frontiers in Neuroscience high frequency repetitive transcranial magnetic stimulation propensity score inverse probability weighting Wilson disease cognitive impairment |
| title | Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scores |
| title_full | Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scores |
| title_fullStr | Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scores |
| title_full_unstemmed | Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scores |
| title_short | Effect of high-frequency repetitive transcranial magnetic stimulation on cognitive impairment in WD patients based on inverse probability weighting of propensity scores |
| title_sort | effect of high frequency repetitive transcranial magnetic stimulation on cognitive impairment in wd patients based on inverse probability weighting of propensity scores |
| topic | high frequency repetitive transcranial magnetic stimulation propensity score inverse probability weighting Wilson disease cognitive impairment |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1375234/full |
| work_keys_str_mv | AT hongchen effectofhighfrequencyrepetitivetranscranialmagneticstimulationoncognitiveimpairmentinwdpatientsbasedoninverseprobabilityweightingofpropensityscores AT xiewang effectofhighfrequencyrepetitivetranscranialmagneticstimulationoncognitiveimpairmentinwdpatientsbasedoninverseprobabilityweightingofpropensityscores AT juanzhang effectofhighfrequencyrepetitivetranscranialmagneticstimulationoncognitiveimpairmentinwdpatientsbasedoninverseprobabilityweightingofpropensityscores AT daojunxie effectofhighfrequencyrepetitivetranscranialmagneticstimulationoncognitiveimpairmentinwdpatientsbasedoninverseprobabilityweightingofpropensityscores |