Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer
Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular al...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14542 |
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| author | Margarida Coelho João Capela Sandra I. Anjo João Pacheco Margarida Sá Fernandes Isabel Amendoeira John G. Jones Luís Raposo Bruno Manadas |
| author_facet | Margarida Coelho João Capela Sandra I. Anjo João Pacheco Margarida Sá Fernandes Isabel Amendoeira John G. Jones Luís Raposo Bruno Manadas |
| author_sort | Margarida Coelho |
| collection | DOAJ |
| description | Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules. |
| first_indexed | 2024-03-10T21:44:07Z |
| format | Article |
| id | doaj.art-dc46729911d845778221c331eb3c22d2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:44:07Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dc46729911d845778221c331eb3c22d22023-11-19T14:28:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191454210.3390/ijms241914542Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid CancerMargarida Coelho0João Capela1Sandra I. Anjo2João Pacheco3Margarida Sá Fernandes4Isabel Amendoeira5John G. Jones6Luís Raposo7Bruno Manadas8CNC—Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalCentro Hospitalar Universitário São João, 4200-319 Porto, PortugalCNC—Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalCentro Hospitalar Universitário São João, 4200-319 Porto, PortugalCentro Hospitalar Universitário São João, 4200-319 Porto, PortugalCentro Hospitalar Universitário São João, 4200-319 Porto, PortugalCNC—Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalPortuguese Society of Endocrinology, Diabetes and Metabolism, 1600-892 Lisbon, PortugalCNC—Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalDifferentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules.https://www.mdpi.com/1422-0067/24/19/14542proteomicsscreeningthyroid cancerannexinsSp1 |
| spellingShingle | Margarida Coelho João Capela Sandra I. Anjo João Pacheco Margarida Sá Fernandes Isabel Amendoeira John G. Jones Luís Raposo Bruno Manadas Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer International Journal of Molecular Sciences proteomics screening thyroid cancer annexins Sp1 |
| title | Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer |
| title_full | Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer |
| title_fullStr | Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer |
| title_full_unstemmed | Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer |
| title_short | Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer |
| title_sort | proteomics reveals mrna regulation and the action of annexins in thyroid cancer |
| topic | proteomics screening thyroid cancer annexins Sp1 |
| url | https://www.mdpi.com/1422-0067/24/19/14542 |
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