Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease.

Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease.

Show other versions (1)

There are currently no preventive or disease-modifying therapies for Parkinson's Disease (PD). Failures in clinical trials necessitate a re-evaluation of existing pre-clinical models in order to adopt systems that better recapitulate underlying disease mechanisms and better predict clinical out...

Full description

Bibliographic Details
Main Authors:	Waseem K Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Kenneth J Rhodes, Vikram Khurana, Robert H Scannevin, Chee Yeun Chung
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0277532

Similar Items

Patient-derived three-dimensional cortical neurospheres to model Parkinson’s disease
by: Waseem K. Raja, et al.
Published: (2022-01-01)

Essential tremor: A three-dimensional neurosphere in vitro model to assess the neurotoxicity of harmane
by: Rania Aro, et al.
Published: (2023-01-01)

Characterization of neural stem cells derived from human stem cells from the apical papilla undergoing three-dimensional neurosphere induction
by: Anupong Thongklam SONGSAAD, et al.
Published: (2023-11-01)

An efficient method for the transduction of primary pediatric glioma neurospheres
by: Michaël H. Meel, et al.
Published: (2018-01-01)

Neural fate commitment of rat full-term amniotic fluid stem cells via three-dimensional embryoid bodies and neurospheres formation
by: Nuratiqah Azmi, et al.
Published: (2023-06-01)

Neural fate commitment of rat full-term amniotic fluid stem cells via three-dimensional embryoid bodies and neurospheres formation
by: Azmi, Nuratiqah, et al.
Published: (2023)

Tracking the Transplanted Neurosphere in Retinal Pigment Epithelium Degeneration Model
by: Hamid Aboutaleb Kadkhodaeian, et al.
Published: (2021-07-01)

Characterisation of Neurospheres-Derived Cells from Human Olfactory Epithelium
by: Elena A. Zelenova, et al.
Published: (2021-07-01)

FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres
by: Aimee L. Dowling, et al.
Published: (2023-11-01)

Development of circadian oscillators in neurosphere cultures during adult neurogenesis.
by: Astha Malik, et al.
Published: (2015-01-01)

Inhibition of Neurosphere Formation in Neural Stem/Progenitor Cells by Acrylamide
by: Jong-Hang Chen, et al.
Published: (2015-05-01)

Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
by: Katharina Koch, et al.
Published: (2022-03-01)

Chikungunya virus infection induces ultrastructural changes and impaired neuronal differentiation of human neurospheres
by: Thaíse Yasmine Vasconcelos de Lima Cavalcanti, et al.
Published: (2023-05-01)

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity
by: Benjamin M. Vincent, et al.
Published: (2018-12-01)

NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease.
by: Anthony L Cook, et al.
Published: (2011-01-01)

Doublecortin is necessary for the migration of adult subventricular zone cells from neurospheres.
by: Ocbina, P, et al.
Published: (2006)

Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro
by: Francisca Espinoza, et al.
Published: (2020-12-01)

Transcriptome Changes in Glioma Cells Cultivated under Conditions of Neurosphere Formation
by: Natalia S. Vasileva, et al.
Published: (2022-10-01)

ApoTransferrin: dual role on adult subventricular zone-derived neurospheres.
by: Lucas Silvestroff, et al.
Published: (2012-01-01)

Genetic alterations and in vivo tumorigenicity of neurospheres derived from an adult glioblastoma
by: Broggi Giovanni, et al.
Published: (2004-10-01)

Non-permissive SARS-CoV-2 infection in human neurospheres
by: Carolina da S.G. Pedrosa, et al.
Published: (2021-07-01)

Generation of UCiPSC-derived neurospheres for cell therapy and its application
by: Shuai Li, et al.
Published: (2021-03-01)

The neurosphere assay: an effective in vitro technique to study neural stem cells
by: Rita Soares, et al.
Published: (2021-01-01)

Correction: Direct Generation of Neurosphere-Like Cells from Human Dermal Fibroblasts
Published: (2012-01-01)

Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment.
by: Carmen Capone, et al.
Published: (2007-01-01)

Regulation of progenitor cell proliferation and neuronal differentiation in enteric nervous system neurospheres.
by: Sokratis Theocharatos, et al.
Published: (2013-01-01)

Runx1 promotes proliferation and neuronal differentiation in adult mouse neurosphere cultures
by: T.T. Logan, et al.
Published: (2015-11-01)

Characterization of seeding conditions for studies on differentiation patterns of subventricular zone derived neurospheres
by: Eduardo H Sanchez-Mendoza, et al.
Published: (2016-03-01)

Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses
by: Georghios Joseph, et al.
Published: (2021-07-01)

Testosterone-induced adult neurosphere growth is mediated by sexually-dimorphic aromatase expression
by: Mark Ian Ransome, et al.
Published: (2015-07-01)

Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy
by: Jeonghoon Choi, et al.
Published: (2023-04-01)

Are the Symptoms of Parkinsonism Cortical in Origin?
by: Gordon W. Arbuthnott, et al.
Published: (2017-01-01)

Enteric neurospheres retain the capacity to assemble neural networks with motile and metamorphic gliocytes and ganglia
by: Jeng-Chang Chen, et al.
Published: (2023-10-01)

Functionalized Graphene Quantum Dots Modulate Malignancy of Glioblastoma Multiforme by Downregulating Neurospheres Formation
by: Giordano Perini, et al.
Published: (2021-01-01)

Integrated Metabolomics and Transcriptomics Analysis of Monolayer and Neurospheres from Established Glioblastoma Cell Lines
by: Joana Peixoto, et al.
Published: (2021-03-01)

Human Mesenchymal Stem Cells Seeded on the Natural Membrane to Neurospheres for Cholinergic-like Neurons
by: Priscila Elias Ferreira Stricker, et al.
Published: (2021-08-01)

Impact of cryopreservation on viability, gene expression and function of enteric nervous system derived neurospheres
by: Sabine Heumüller-Klug, et al.
Published: (2023-06-01)

Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies.
by: Ellen Binder, et al.
Published: (2015-01-01)

Dexamethasone-mediated inhibition of Glioblastoma neurosphere dispersal in an ex vivo organotypic neural assay.
by: Ahmed M Meleis, et al.
Published: (2017-01-01)

Cortical network formation based on subthalamic beta bursts in Parkinson's disease
by: Matthias Sure, et al.
Published: (2022-11-01)