Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections?
Objective: Newborns with congenital hypogonadotropic hypogonadism (CHH) have an impaired postnatal activation of the gonadotropic axis. Substitutive therapy with recombinant gonadotropins can be proposed to mimic physiological male mini-puberty during the first months of life. The aim of this study...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-03-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/4/EC-22-0252.xml |
| _version_ | 1797867209109798912 |
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| author | Tristan Avril Quentin Hennocq Anne-Sophie Lambert Juliane Leger Dominique Simon Laetitia Martinerie Claire Bouvattier |
| author_facet | Tristan Avril Quentin Hennocq Anne-Sophie Lambert Juliane Leger Dominique Simon Laetitia Martinerie Claire Bouvattier |
| author_sort | Tristan Avril |
| collection | DOAJ |
| description | Objective: Newborns with congenital hypogonadotropic hypogonadism (CHH) have an impaired postnatal activation of the gonadotropic axis. Substitutive therapy with recombinant gonadotropins can be proposed to mimic physiological male mini-puberty during the first months of life. The aim of this study was to co mpare the clinical and biological efficacy of two treatment modalities of gonadotropins administration during mini-puberty in CHH neonates.
Design: Multicenter retrospective analytical epidemiological study comparing two treatments, pump vs injection, between 2004 and 2019.
Methods: Clinical (penile size, testis size, testicular descent) and biological parameters (serum concentrations of testosterone, anti-Müllerian hormone (AMH) and Inhibin B) were compared between the two groups by multivariate analyses.
Results: Thirty-five patients were included. A significantly higher incre ase in penile length and testosterone level was observed in the injection group compared to the pump group (+0.16 ± 0.02 mm vs +0.10 ± 0.02 mm per day, P = 0.002; and +0.04 ± 0.007 ng/mL vs +0.01 ± 0.008 ng/mL per day, P = 0.001). In both groups, significant increases in penile length and width, testosterone, AMH, and Inhibin B levels were observed, as well as improved testicular descent (odds ratio of not being in a scrotal position at the end of treatment = 0.97 (0.96; 0.99)).
Conclusions: Early postnatal administration of recombinant gonadotropins in CHH boys is effective in stimulating penile growth, Sertoli cell proliferati on, and testicular descent, with both treatment modalities. |
| first_indexed | 2024-04-09T23:36:40Z |
| format | Article |
| id | doaj.art-dc4aa041c1c1469d89bf272727402729 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-09T23:36:40Z |
| publishDate | 2023-03-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-dc4aa041c1c1469d89bf2727274027292023-03-20T06:30:32ZengBioscientificaEndocrine Connections2049-36142023-03-0112419https://doi.org/10.1530/EC-22-0252Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections?Tristan Avril0Quentin Hennocq1Anne-Sophie Lambert2Juliane Leger3Dominique Simon4Laetitia Martinerie5Claire Bouvattier6Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, FranceDatascience platform, Imagine Institute, Université Paris Cité, Paris, FrancePediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, FrancePediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France; Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France Pediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, FrancePediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France; Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France; Inserm UMR1185, Le Kremlin Bicetre, Paris, France Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, France; Inserm UMR1185, Le Kremlin Bicetre, Paris, France; Paris-Saclay University, Paris, France Objective: Newborns with congenital hypogonadotropic hypogonadism (CHH) have an impaired postnatal activation of the gonadotropic axis. Substitutive therapy with recombinant gonadotropins can be proposed to mimic physiological male mini-puberty during the first months of life. The aim of this study was to co mpare the clinical and biological efficacy of two treatment modalities of gonadotropins administration during mini-puberty in CHH neonates. Design: Multicenter retrospective analytical epidemiological study comparing two treatments, pump vs injection, between 2004 and 2019. Methods: Clinical (penile size, testis size, testicular descent) and biological parameters (serum concentrations of testosterone, anti-Müllerian hormone (AMH) and Inhibin B) were compared between the two groups by multivariate analyses. Results: Thirty-five patients were included. A significantly higher incre ase in penile length and testosterone level was observed in the injection group compared to the pump group (+0.16 ± 0.02 mm vs +0.10 ± 0.02 mm per day, P = 0.002; and +0.04 ± 0.007 ng/mL vs +0.01 ± 0.008 ng/mL per day, P = 0.001). In both groups, significant increases in penile length and width, testosterone, AMH, and Inhibin B levels were observed, as well as improved testicular descent (odds ratio of not being in a scrotal position at the end of treatment = 0.97 (0.96; 0.99)). Conclusions: Early postnatal administration of recombinant gonadotropins in CHH boys is effective in stimulating penile growth, Sertoli cell proliferati on, and testicular descent, with both treatment modalities.https://ec.bioscientifica.com/view/journals/ec/12/4/EC-22-0252.xmlrecombinant gonadotropinsmini-pubertyboyshypogonadotropic hypogonadismpumpinjections |
| spellingShingle | Tristan Avril Quentin Hennocq Anne-Sophie Lambert Juliane Leger Dominique Simon Laetitia Martinerie Claire Bouvattier Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections? Endocrine Connections recombinant gonadotropins mini-puberty boys hypogonadotropic hypogonadism pump injections |
| title | Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections? |
| title_full | Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections? |
| title_fullStr | Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections? |
| title_full_unstemmed | Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections? |
| title_short | Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections? |
| title_sort | gonadotropin administration to mimic mini puberty in hypogonadotropic males pump or injections |
| topic | recombinant gonadotropins mini-puberty boys hypogonadotropic hypogonadism pump injections |
| url | https://ec.bioscientifica.com/view/journals/ec/12/4/EC-22-0252.xml |
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