Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome
Abstract Exposure to heavy metals (HMs) is a threat to human health. Although probiotics can detoxify HMs in animals, their effectiveness and mechanism of action in humans have not been studied well. Therefore, we conducted this randomized, double-blind, controlled trial on 152 occupational workers...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-022-00326-8 |
| _version_ | 1811283849878962176 |
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| author | Pengya Feng Jinfeng Yang Shuai Zhao Zhenmin Ling Rong Han Ying Wu Ei-Sayed Salama Apurva Kakade Aman Khan Weilin Jin Weibing Zhang Byong-Hun Jeon Jingjing Fan Minrui Liu Tursunay Mamtimin Pu Liu Xiangkai Li |
| author_facet | Pengya Feng Jinfeng Yang Shuai Zhao Zhenmin Ling Rong Han Ying Wu Ei-Sayed Salama Apurva Kakade Aman Khan Weilin Jin Weibing Zhang Byong-Hun Jeon Jingjing Fan Minrui Liu Tursunay Mamtimin Pu Liu Xiangkai Li |
| author_sort | Pengya Feng |
| collection | DOAJ |
| description | Abstract Exposure to heavy metals (HMs) is a threat to human health. Although probiotics can detoxify HMs in animals, their effectiveness and mechanism of action in humans have not been studied well. Therefore, we conducted this randomized, double-blind, controlled trial on 152 occupational workers from the metal industry, an at-risk human population, to explore the effectiveness of probiotic yogurt in reducing HM levels. Participants were randomly assigned to two groups: one consumed probiotic yogurt containing the HM-resistant strain Pediococcus acidilactici GR-1 and the other consumed conventional yogurt for 12 weeks. Analysis of metal contents in the blood revealed that the consumption of probiotic yogurt resulted in a higher and faster decrease in copper (34.45%) and nickel (38.34%) levels in the blood than the consumption of conventional yogurt (16.41% and 27.57%, respectively). Metagenomic and metabolomic studies identified a close correlation between gut microbiota (GM) and host metabolism. Significantly enriched members of Blautia and Bifidobacterium correlated positively with the antioxidant capacities of GM and host. Further murine experiments confirmed the essential role of GM and protective effect of GR-1 on the antioxidative role of the intestine against copper. Thus, the use of probiotic yogurt may be an effective and affordable approach for combating toxic metal exposure through the protection of indigenous GM in humans. ClinicalTrials.gov identifier: ChiCTR2100053222 |
| first_indexed | 2024-04-13T02:18:33Z |
| format | Article |
| id | doaj.art-dc4b04d9119143dabaf53bf23861b5a8 |
| institution | Directory Open Access Journal |
| issn | 2055-5008 |
| language | English |
| last_indexed | 2024-04-13T02:18:33Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj.art-dc4b04d9119143dabaf53bf23861b5a82022-12-22T03:07:04ZengNature Portfolionpj Biofilms and Microbiomes2055-50082022-08-018111810.1038/s41522-022-00326-8Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolomePengya Feng0Jinfeng Yang1Shuai Zhao2Zhenmin Ling3Rong Han4Ying Wu5Ei-Sayed Salama6Apurva Kakade7Aman Khan8Weilin Jin9Weibing Zhang10Byong-Hun Jeon11Jingjing Fan12Minrui Liu13Tursunay Mamtimin14Pu Liu15Xiangkai Li16Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityCollege of Life Science and Technology, Gansu Agricultural UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityDepartment of Occupational and Environmental Health, School of Public Health, Lanzhou UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityInstitute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou UniversityCollege of Life Science and Technology, Gansu Agricultural UniversityDepartment of Earth Resources and Environmental Engineering, Hanyang UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityCollege of Life Science and Technology, Gansu Agricultural UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou UniversityAbstract Exposure to heavy metals (HMs) is a threat to human health. Although probiotics can detoxify HMs in animals, their effectiveness and mechanism of action in humans have not been studied well. Therefore, we conducted this randomized, double-blind, controlled trial on 152 occupational workers from the metal industry, an at-risk human population, to explore the effectiveness of probiotic yogurt in reducing HM levels. Participants were randomly assigned to two groups: one consumed probiotic yogurt containing the HM-resistant strain Pediococcus acidilactici GR-1 and the other consumed conventional yogurt for 12 weeks. Analysis of metal contents in the blood revealed that the consumption of probiotic yogurt resulted in a higher and faster decrease in copper (34.45%) and nickel (38.34%) levels in the blood than the consumption of conventional yogurt (16.41% and 27.57%, respectively). Metagenomic and metabolomic studies identified a close correlation between gut microbiota (GM) and host metabolism. Significantly enriched members of Blautia and Bifidobacterium correlated positively with the antioxidant capacities of GM and host. Further murine experiments confirmed the essential role of GM and protective effect of GR-1 on the antioxidative role of the intestine against copper. Thus, the use of probiotic yogurt may be an effective and affordable approach for combating toxic metal exposure through the protection of indigenous GM in humans. ClinicalTrials.gov identifier: ChiCTR2100053222https://doi.org/10.1038/s41522-022-00326-8 |
| spellingShingle | Pengya Feng Jinfeng Yang Shuai Zhao Zhenmin Ling Rong Han Ying Wu Ei-Sayed Salama Apurva Kakade Aman Khan Weilin Jin Weibing Zhang Byong-Hun Jeon Jingjing Fan Minrui Liu Tursunay Mamtimin Pu Liu Xiangkai Li Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome npj Biofilms and Microbiomes |
| title | Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome |
| title_full | Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome |
| title_fullStr | Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome |
| title_full_unstemmed | Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome |
| title_short | Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome |
| title_sort | human supplementation with pediococcus acidilactici gr 1 decreases heavy metals levels through modifying the gut microbiota and metabolome |
| url | https://doi.org/10.1038/s41522-022-00326-8 |
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