Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion

Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion

Highlights • Quercetin (QCN) promotes motoneuron survival and accelerates axonal regeneration after brachial plexus root avulsion/re-implantation in rats. • QCN improves motor function recovery of the forelimb. • QCN exhibits neuroprotective effects via inhibiting neuroinflammation and upregulating...

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Bibliographic Details
Main Authors: Yanfeng Huang, Xie Zhang, Qionghui Huang, Yaoxing Dou, Chang Qu, Qingqing Xu, Qiuju Yuan, Yan-Fang Xian, Zhi-Xiu Lin
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Inflammation and Regeneration
Subjects:
Brachial plexus avulsion
Quercetin
Motoneuron
Oxidative damage
Inflammatory response
Online Access:https://doi.org/10.1186/s41232-022-00245-3
Description
Summary:Highlights • Quercetin (QCN) promotes motoneuron survival and accelerates axonal regeneration after brachial plexus root avulsion/re-implantation in rats. • QCN improves motor function recovery of the forelimb. • QCN exhibits neuroprotective effects via inhibiting neuroinflammation and upregulating the neurotrophins. • QCN alleviates the avulsion-induced oxidative damage in rats. • QCN inhibits the avulsion-induced neuronal apoptosis in rats. • QCN modulates Nrf2/HO-1 and neurotrophin/Akt/MAPK signaling pathways.
ISSN:1880-8190

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