The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature Review
SARS-CoV-2/Coronavirus 2019 (COVID-19) is responsible for the pandemic, which started in December 2019. In addition to the typical respiratory symptoms, this virus also causes other severe complications, including neurological ones. In diagnostics, serological and polymerase chain reaction tests are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5894 |
| _version_ | 1797531952839917568 |
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| author | Joanna Kulikowska Agnieszka Kulczyńska-Przybik Barbara Mroczko Alina Kułakowska |
| author_facet | Joanna Kulikowska Agnieszka Kulczyńska-Przybik Barbara Mroczko Alina Kułakowska |
| author_sort | Joanna Kulikowska |
| collection | DOAJ |
| description | SARS-CoV-2/Coronavirus 2019 (COVID-19) is responsible for the pandemic, which started in December 2019. In addition to the typical respiratory symptoms, this virus also causes other severe complications, including neurological ones. In diagnostics, serological and polymerase chain reaction tests are useful not only in detecting past infections but can also predict the response to vaccination. It is now believed that an immune mechanism rather than direct viral neuroinvasion is responsible for neurological symptoms. For this reason, it is important to assess the presence of antibodies not only in the serum but also in the cerebrospinal fluid (CSF), especially in the case of neuro-COVID. A particular group of patients are people with multiple sclerosis (MS) whose disease-modifying drugs weaken the immune system and lead to an unpredictable serological response to SARS-CoV-2 infection. Based on available data, the article summarizes the current serological information concerning COVID-19 in CSF in patients with severe neurological complications and in those with MS. |
| first_indexed | 2024-03-10T10:52:09Z |
| format | Article |
| id | doaj.art-dc4c3c44b3084746aa19deec032acaa1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:52:09Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dc4c3c44b3084746aa19deec032acaa12023-11-21T22:11:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211589410.3390/ijms22115894The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature ReviewJoanna Kulikowska0Agnieszka Kulczyńska-Przybik1Barbara Mroczko2Alina Kułakowska3Department of Neurology, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, PolandDepartment of Neurology, Medical University of Bialystok, 15-276 Bialystok, PolandSARS-CoV-2/Coronavirus 2019 (COVID-19) is responsible for the pandemic, which started in December 2019. In addition to the typical respiratory symptoms, this virus also causes other severe complications, including neurological ones. In diagnostics, serological and polymerase chain reaction tests are useful not only in detecting past infections but can also predict the response to vaccination. It is now believed that an immune mechanism rather than direct viral neuroinvasion is responsible for neurological symptoms. For this reason, it is important to assess the presence of antibodies not only in the serum but also in the cerebrospinal fluid (CSF), especially in the case of neuro-COVID. A particular group of patients are people with multiple sclerosis (MS) whose disease-modifying drugs weaken the immune system and lead to an unpredictable serological response to SARS-CoV-2 infection. Based on available data, the article summarizes the current serological information concerning COVID-19 in CSF in patients with severe neurological complications and in those with MS.https://www.mdpi.com/1422-0067/22/11/5894COVID-19SARS-CoV-2neuro-COVIDserologyantibodiescerebrospinal fluid |
| spellingShingle | Joanna Kulikowska Agnieszka Kulczyńska-Przybik Barbara Mroczko Alina Kułakowska The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature Review International Journal of Molecular Sciences COVID-19 SARS-CoV-2 neuro-COVID serology antibodies cerebrospinal fluid |
| title | The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature Review |
| title_full | The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature Review |
| title_fullStr | The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature Review |
| title_full_unstemmed | The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature Review |
| title_short | The Significance of COVID-19 Immunological Status in Severe Neurological Complications and Multiple Sclerosis—A Literature Review |
| title_sort | significance of covid 19 immunological status in severe neurological complications and multiple sclerosis a literature review |
| topic | COVID-19 SARS-CoV-2 neuro-COVID serology antibodies cerebrospinal fluid |
| url | https://www.mdpi.com/1422-0067/22/11/5894 |
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