New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate
As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge. The objective of this study was to determine whether the solubility of megestrol acetate, a Biopharmaceutical Classification System (BCS)...
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| Format: | Article |
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MDPI AG
2016-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/2/197 |
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| author | Malwina Lachowicz Michał Kołodziejczyk Marek Lukosek Jacek Kosno Paulina Olszewska Paweł Szymański |
| author_facet | Malwina Lachowicz Michał Kołodziejczyk Marek Lukosek Jacek Kosno Paulina Olszewska Paweł Szymański |
| author_sort | Malwina Lachowicz |
| collection | DOAJ |
| description | As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge. The objective of this study was to determine whether the solubility of megestrol acetate, a Biopharmaceutical Classification System (BCS) class II drug, can be improved by using a newly-synthesized surfactant (Rofam 70: a rapeseed methyl ester ethoxylate) and compare it with two references surfactants (Tween 80, Pluronic F68) at three different pH values. Spectrophotometry was used to compare the solubility profiles in the presence of three tested surfactants at pH 5.0, 7.4 and 9.0. Rapeseed methyl ester ethoxylate was found to improve the solubility of the BCS Class II drug and increase its bioavailability; It increased drug solubility more effectively than Pluronic F68. Its cytotoxicity results indicate its possible value as a surfactant in Medicine and Pharmacy. |
| first_indexed | 2024-04-13T19:10:41Z |
| format | Article |
| id | doaj.art-dc4f696492864dc481f056f9b64337b5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T19:10:41Z |
| publishDate | 2016-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-dc4f696492864dc481f056f9b64337b52022-12-22T02:33:51ZengMDPI AGMolecules1420-30492016-02-0121219710.3390/molecules21020197molecules21020197New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol AcetateMalwina Lachowicz0Michał Kołodziejczyk1Marek Lukosek2Jacek Kosno3Paulina Olszewska4Paweł Szymański5Department of Applied Pharmacy, Medical University of Lodz, ul. Muszyńskiego 1, Lodz 90-151, PolandDepartment of Applied Pharmacy, Medical University of Lodz, ul. Muszyńskiego 1, Lodz 90-151, PolandSurface-Active Agent Plant “ICSO Blachownia”, ul. Energetyków 9, Kędzierzyn-Koźle 47-225, PolandSurface-Active Agent Plant “ICSO Blachownia”, ul. Energetyków 9, Kędzierzyn-Koźle 47-225, PolandDepartment of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszyńskiego 1, Lodz 90-151, PolandLaboratory of Radiopharmacy, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszyńskiego 1, Lodz 90-151, PolandAs many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge. The objective of this study was to determine whether the solubility of megestrol acetate, a Biopharmaceutical Classification System (BCS) class II drug, can be improved by using a newly-synthesized surfactant (Rofam 70: a rapeseed methyl ester ethoxylate) and compare it with two references surfactants (Tween 80, Pluronic F68) at three different pH values. Spectrophotometry was used to compare the solubility profiles in the presence of three tested surfactants at pH 5.0, 7.4 and 9.0. Rapeseed methyl ester ethoxylate was found to improve the solubility of the BCS Class II drug and increase its bioavailability; It increased drug solubility more effectively than Pluronic F68. Its cytotoxicity results indicate its possible value as a surfactant in Medicine and Pharmacy.http://www.mdpi.com/1420-3049/21/2/197solubilizationsurfactantnanoparticlesmegestrol acetateTween 80 |
| spellingShingle | Malwina Lachowicz Michał Kołodziejczyk Marek Lukosek Jacek Kosno Paulina Olszewska Paweł Szymański New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate Molecules solubilization surfactant nanoparticles megestrol acetate Tween 80 |
| title | New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate |
| title_full | New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate |
| title_fullStr | New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate |
| title_full_unstemmed | New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate |
| title_short | New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate |
| title_sort | new biopolymer nanoparticles improve the solubility of lipophilic megestrol acetate |
| topic | solubilization surfactant nanoparticles megestrol acetate Tween 80 |
| url | http://www.mdpi.com/1420-3049/21/2/197 |
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