The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis
Background Platelet-rich plasma (PRP) is a therapeutic approach that is gaining attention for its potential in the treatment of poor ovarian response. This meta-analysis aimed to systematically review and analyze clinical studies to evaluate the impact of PRP on poor responders undergoing ovarian st...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Platelets |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09537104.2023.2292612 |
| _version_ | 1826930429895114752 |
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| author | Lingling Wu Fenfang Su Peixin Luo Qingqing Dong Mengni Ma Guangyong Ye |
| author_facet | Lingling Wu Fenfang Su Peixin Luo Qingqing Dong Mengni Ma Guangyong Ye |
| author_sort | Lingling Wu |
| collection | DOAJ |
| description | Background Platelet-rich plasma (PRP) is a therapeutic approach that is gaining attention for its potential in the treatment of poor ovarian response. This meta-analysis aimed to systematically review and analyze clinical studies to evaluate the impact of PRP on poor responders undergoing ovarian stimulation for IVF.Methods A comprehensive search was conducted in electronic databases, including PubMed, Embase, Scopus, Web of Science, and the Cochrane Library to identify relevant studies published in English. The pooled data, such as pregnancy outcome, number of MII oocytes, number of transferable embryos, and ovarian reserve markers were analyzed using R version 4.2.3.Results A total of 10 trials were enrolled in the present meta-analysis. Following PRP treatment, live birth rate was found to be 16.6% (95% CI 8.8%-26.1%), while clinical pregnancy rate was observed to be 25.4% (95% CI 13.1%-39.9%). PRP pretreatment resulted in a higher number of MII oocytes (MD 1.073, 95% CI 0.720 to 1.427), a higher number of embryos (MD 0.946, 95% CI 0.569 to 1.323), a higher antral follicle count (MD 1.117; 95% CI 0.689 to 1.544), and the change of hormone levels.Conclusions Among the studies evaluated in this review, PRP showed promising results in poor responder. Further research is required to clarify the potential role of PRP in female reproductive health. |
| first_indexed | 2024-03-08T14:29:30Z |
| format | Article |
| id | doaj.art-dc516dced8944bd8adfeb9088b60655c |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2025-02-17T16:27:38Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-dc516dced8944bd8adfeb9088b60655c2024-12-17T06:39:35ZengTaylor & Francis GroupPlatelets0953-71041369-16352024-12-0135110.1080/09537104.2023.2292612The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysisLingling Wu0Fenfang Su1Peixin Luo2Qingqing Dong3Mengni Ma4Guangyong Ye5Department of Blood Transfusion, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Blood Transfusion, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Blood Transfusion, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Blood Transfusion, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Blood Transfusion, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Blood Transfusion, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBackground Platelet-rich plasma (PRP) is a therapeutic approach that is gaining attention for its potential in the treatment of poor ovarian response. This meta-analysis aimed to systematically review and analyze clinical studies to evaluate the impact of PRP on poor responders undergoing ovarian stimulation for IVF.Methods A comprehensive search was conducted in electronic databases, including PubMed, Embase, Scopus, Web of Science, and the Cochrane Library to identify relevant studies published in English. The pooled data, such as pregnancy outcome, number of MII oocytes, number of transferable embryos, and ovarian reserve markers were analyzed using R version 4.2.3.Results A total of 10 trials were enrolled in the present meta-analysis. Following PRP treatment, live birth rate was found to be 16.6% (95% CI 8.8%-26.1%), while clinical pregnancy rate was observed to be 25.4% (95% CI 13.1%-39.9%). PRP pretreatment resulted in a higher number of MII oocytes (MD 1.073, 95% CI 0.720 to 1.427), a higher number of embryos (MD 0.946, 95% CI 0.569 to 1.323), a higher antral follicle count (MD 1.117; 95% CI 0.689 to 1.544), and the change of hormone levels.Conclusions Among the studies evaluated in this review, PRP showed promising results in poor responder. Further research is required to clarify the potential role of PRP in female reproductive health.https://www.tandfonline.com/doi/10.1080/09537104.2023.2292612In vitro fertilizationovulation inductionplatelet rich plasmapoor ovarian response |
| spellingShingle | Lingling Wu Fenfang Su Peixin Luo Qingqing Dong Mengni Ma Guangyong Ye The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis Platelets In vitro fertilization ovulation induction platelet rich plasma poor ovarian response |
| title | The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis |
| title_full | The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis |
| title_fullStr | The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis |
| title_full_unstemmed | The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis |
| title_short | The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis |
| title_sort | efficacy of platelet rich plasma on women with poor ovarian response a systematic review and meta analysis |
| topic | In vitro fertilization ovulation induction platelet rich plasma poor ovarian response |
| url | https://www.tandfonline.com/doi/10.1080/09537104.2023.2292612 |
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