Evaluation of Triclosan Effects on Cultured Swine Luteal Cells
Triclosan is a chlorinated phenolic, used in many personal and home care products for its powerful antimicrobial effect. Several studies have shown triclosan toxicity and the American Food and Drug Administration (FDA) in 2016 has limited its use. It has been recently included in endocrine-disruptin...
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MDPI AG
2021-02-01
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Online Access: | https://www.mdpi.com/2076-2615/11/3/606 |
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author | Giuseppina Basini Simona Bussolati Simone Bertini Fausto Quintavalla Francesca Grasselli |
author_facet | Giuseppina Basini Simona Bussolati Simone Bertini Fausto Quintavalla Francesca Grasselli |
author_sort | Giuseppina Basini |
collection | DOAJ |
description | Triclosan is a chlorinated phenolic, used in many personal and home care products for its powerful antimicrobial effect. Several studies have shown triclosan toxicity and the American Food and Drug Administration (FDA) in 2016 has limited its use. It has been recently included in endocrine-disrupting chemicals (EDCs), a list of chemicals known for their ability to interfere with hormonal signaling with particular critical effects on reproduction both in animals and humans. In order to deepen the knowledge in this specific field, the present study was undertaken to explore the effect of different concentrations of triclosan (1, 10, and 50 µM) on cultured luteal cells, isolated from swine ovaries, evaluating effects on growth Bromodeoxyuridine (BrDU) incorporation and Adenosine TriPhosphate (ATP) production, steroidogenesis (progesterone secretion) and redox status (superoxide and nitric oxide production, enzymatic and non-enzymatic scavenging activity). A biphasic effect was exerted by triclosan on P4 production. In fact, the highest concentration inhibited, while the others stimulated P4 production (<i>p</i> < 0.05). Triclosan significantly inhibited cell proliferation, metabolic activity, and enzymatic scavenger activity (<i>p</i> < 0.05). On the contrary, nitric oxide production was significantly increased by triclosan (<i>p</i> < 0.01), while superoxide anion generation and non-enzymatic scavenging activity were unaffected. |
first_indexed | 2024-03-09T00:34:01Z |
format | Article |
id | doaj.art-dc522a4c2a1f4c82807e3ec571a1eb7c |
institution | Directory Open Access Journal |
issn | 2076-2615 |
language | English |
last_indexed | 2024-03-09T00:34:01Z |
publishDate | 2021-02-01 |
publisher | MDPI AG |
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spelling | doaj.art-dc522a4c2a1f4c82807e3ec571a1eb7c2023-12-11T18:21:34ZengMDPI AGAnimals2076-26152021-02-0111360610.3390/ani11030606Evaluation of Triclosan Effects on Cultured Swine Luteal CellsGiuseppina Basini0Simona Bussolati1Simone Bertini2Fausto Quintavalla3Francesca Grasselli4Dipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126 Parma, ItalyDipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126 Parma, ItalyDipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126 Parma, ItalyDipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126 Parma, ItalyDipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126 Parma, ItalyTriclosan is a chlorinated phenolic, used in many personal and home care products for its powerful antimicrobial effect. Several studies have shown triclosan toxicity and the American Food and Drug Administration (FDA) in 2016 has limited its use. It has been recently included in endocrine-disrupting chemicals (EDCs), a list of chemicals known for their ability to interfere with hormonal signaling with particular critical effects on reproduction both in animals and humans. In order to deepen the knowledge in this specific field, the present study was undertaken to explore the effect of different concentrations of triclosan (1, 10, and 50 µM) on cultured luteal cells, isolated from swine ovaries, evaluating effects on growth Bromodeoxyuridine (BrDU) incorporation and Adenosine TriPhosphate (ATP) production, steroidogenesis (progesterone secretion) and redox status (superoxide and nitric oxide production, enzymatic and non-enzymatic scavenging activity). A biphasic effect was exerted by triclosan on P4 production. In fact, the highest concentration inhibited, while the others stimulated P4 production (<i>p</i> < 0.05). Triclosan significantly inhibited cell proliferation, metabolic activity, and enzymatic scavenger activity (<i>p</i> < 0.05). On the contrary, nitric oxide production was significantly increased by triclosan (<i>p</i> < 0.01), while superoxide anion generation and non-enzymatic scavenging activity were unaffected.https://www.mdpi.com/2076-2615/11/3/606corpus luteumprogesteronenitric oxidesuperoxide anionredox status |
spellingShingle | Giuseppina Basini Simona Bussolati Simone Bertini Fausto Quintavalla Francesca Grasselli Evaluation of Triclosan Effects on Cultured Swine Luteal Cells Animals corpus luteum progesterone nitric oxide superoxide anion redox status |
title | Evaluation of Triclosan Effects on Cultured Swine Luteal Cells |
title_full | Evaluation of Triclosan Effects on Cultured Swine Luteal Cells |
title_fullStr | Evaluation of Triclosan Effects on Cultured Swine Luteal Cells |
title_full_unstemmed | Evaluation of Triclosan Effects on Cultured Swine Luteal Cells |
title_short | Evaluation of Triclosan Effects on Cultured Swine Luteal Cells |
title_sort | evaluation of triclosan effects on cultured swine luteal cells |
topic | corpus luteum progesterone nitric oxide superoxide anion redox status |
url | https://www.mdpi.com/2076-2615/11/3/606 |
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