Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells

Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells

IntroductionBreast cancer is the most common malignancy in women, and it is linked to several risk factors including genetic alterations, obesity, estrogen signaling, insulin levels, and glucose metabolism deregulation. Insulin and Insulin-like growth factor signaling exert a mitogenic and pro-survi...

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Bibliographic Details
Main Authors: Stefania Stella, Michele Massimino, Livia Manzella, Nunziatina Laura Parrinello, Silvia Rita Vitale, Federica Martorana, Paolo Vigneri
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
breast cancer
tamoxifen resistance
insulin receptors
glucose level
gene expression regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1081831/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1081831/full

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