Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface
Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling, noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the past decade, epigenetic modifications have drawn more attention as they participate in the development and progression of diabetic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1441;epage=1449;aulast=Liu |
| _version_ | 1797954756005593088 |
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| author | Dan-Dan Liu Chao-Yang Zhang Jing-Ting Zhang Li-Min Gu Guo-Tong Xu Jing-Fa Zhang |
| author_facet | Dan-Dan Liu Chao-Yang Zhang Jing-Ting Zhang Li-Min Gu Guo-Tong Xu Jing-Fa Zhang |
| author_sort | Dan-Dan Liu |
| collection | DOAJ |
| description | Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling, noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the past decade, epigenetic modifications have drawn more attention as they participate in the development and progression of diabetic retinopathy despite tight control of glucose levels. The underlying mechanisms of epigenetic modifications in diabetic retinopathy still urgently need to be elucidated. The diabetic condition facilitates epigenetic changes and influences target gene expression. In this review, we summarize the involvement of epigenetic modifications and metabolic memory in the development and progression of diabetic retinopathy and propose novel insights into the treatment of diabetic retinopathy. |
| first_indexed | 2024-04-10T23:23:33Z |
| format | Article |
| id | doaj.art-dc52c1cd982c4e24ae8076e449d1c4df |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-10T23:23:33Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-dc52c1cd982c4e24ae8076e449d1c4df2023-01-12T13:29:30ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-011871441144910.4103/1673-5374.361536Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surfaceDan-Dan LiuChao-Yang ZhangJing-Ting ZhangLi-Min GuGuo-Tong XuJing-Fa ZhangEpigenetics focuses on DNA methylation, histone modification, chromatin remodeling, noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the past decade, epigenetic modifications have drawn more attention as they participate in the development and progression of diabetic retinopathy despite tight control of glucose levels. The underlying mechanisms of epigenetic modifications in diabetic retinopathy still urgently need to be elucidated. The diabetic condition facilitates epigenetic changes and influences target gene expression. In this review, we summarize the involvement of epigenetic modifications and metabolic memory in the development and progression of diabetic retinopathy and propose novel insights into the treatment of diabetic retinopathy.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1441;epage=1449;aulast=Liudiabetic retinopathy; dna methylation; epigenetics; histone modification; metabolic memory; m6a modification; non-coding rnas; review |
| spellingShingle | Dan-Dan Liu Chao-Yang Zhang Jing-Ting Zhang Li-Min Gu Guo-Tong Xu Jing-Fa Zhang Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface Neural Regeneration Research diabetic retinopathy; dna methylation; epigenetics; histone modification; metabolic memory; m6a modification; non-coding rnas; review |
| title | Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface |
| title_full | Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface |
| title_fullStr | Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface |
| title_full_unstemmed | Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface |
| title_short | Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface |
| title_sort | epigenetic modifications and metabolic memory in diabetic retinopathy beyond the surface |
| topic | diabetic retinopathy; dna methylation; epigenetics; histone modification; metabolic memory; m6a modification; non-coding rnas; review |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1441;epage=1449;aulast=Liu |
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