ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing’s syndrome

ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing’s syndrome

Abstract Background Cushing’s syndrome in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. In both species, treatment of pituitary- and adrenal-dependent disease is met with limitations...

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Bibliographic Details
Main Authors: Daniel K. Langlois, Michele C. Fritz, William D. Schall, N. Bari Olivier, Rebecca C. Smedley, Paul G. Pearson, Marc B. Bailie, Stephen W. Hunt
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Endocrine Disorders
Subjects:
Hyperadrenocorticism
Adrenocortical carcinoma
Canine models of adrenal disease
Online Access:http://link.springer.com/article/10.1186/s12902-018-0251-5

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http://link.springer.com/article/10.1186/s12902-018-0251-5

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