Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2013-01-01
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| Series: | Journal of Central Nervous System Disease |
| Online Access: | https://doi.org/10.4137/JCNSD.S11861 |
| _version_ | 1818912760396775424 |
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| author | Mitra Assadi Dah-Jyuu Wang Yadira Velazquez-Rodriquez Paola Leone |
| author_facet | Mitra Assadi Dah-Jyuu Wang Yadira Velazquez-Rodriquez Paola Leone |
| author_sort | Mitra Assadi |
| collection | DOAJ |
| description | Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD. |
| first_indexed | 2024-12-19T23:19:43Z |
| format | Article |
| id | doaj.art-dc54772f8a4e40d481c59189e65db103 |
| institution | Directory Open Access Journal |
| issn | 1179-5735 |
| language | English |
| last_indexed | 2024-12-19T23:19:43Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Central Nervous System Disease |
| spelling | doaj.art-dc54772f8a4e40d481c59189e65db1032022-12-21T20:02:01ZengSAGE PublishingJournal of Central Nervous System Disease1179-57352013-01-01510.4137/JCNSD.S11861Multi-Voxel 1H-MRS in Metachromatic LeukodystrophyMitra Assadi0Dah-Jyuu Wang1Yadira Velazquez-Rodriquez2Paola Leone3Departments of Neurology and Pediatrics, Robert Wood Johnson Medical School.Department of Radiology, University of Pennsylvania.Department of Neurology, Rowan Medical School.School of Osteopathic Medicine, Rowan University.Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD.https://doi.org/10.4137/JCNSD.S11861 |
| spellingShingle | Mitra Assadi Dah-Jyuu Wang Yadira Velazquez-Rodriquez Paola Leone Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy Journal of Central Nervous System Disease |
| title | Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy |
| title_full | Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy |
| title_fullStr | Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy |
| title_full_unstemmed | Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy |
| title_short | Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy |
| title_sort | multi voxel 1h mrs in metachromatic leukodystrophy |
| url | https://doi.org/10.4137/JCNSD.S11861 |
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