Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19
Introduction. Damage to the vascular endothelium and hypercoagulation are two of the main causes of post-COVID-19 complications. The aim of our study was to evaluate endothelial dysfunction and thrombotic complications at different periods after COVID-19 in patients with type 2 diabetes mellitus. P...
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| Format: | Article |
| Language: | English |
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Scientia Publishing House
2023-08-01
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| Series: | Juvenis Scientia |
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| Online Access: | https://jscientia.org/index.php/js/user/setLocale/en_US?source=/index.php/js/article/view/205 |
| _version_ | 1797672997527486464 |
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| author | Alieva, A.V. |
| author_facet | Alieva, A.V. |
| author_sort | Alieva, A.V. |
| collection | DOAJ |
| description | Introduction. Damage to the vascular endothelium and hypercoagulation are two of the main causes of post-COVID-19 complications. The aim of our study was to evaluate endothelial dysfunction and thrombotic complications at different periods after COVID-19 in patients with type 2 diabetes mellitus. Patients and methods. We conducted a cross-sectional study of 135 patients with type 2 diabetes mellitus who applied for inpatient treatment at the RSSPMCE clinic (Tashkent, Uzbekistan) in the period from 3 to 24 months after the acute period of COVID-19. The following laboratory parameters were assessed: fibrinogen, INR, APTT, D-dimer, von Willebrand factor, and cell adhesion molecules (VCAM-1, ICAM-1). Results. Despite normal or near-normal INR, APTT and fibrinogen levels, many patients had elevated levels of D-dimer (41.4 % of cases), von Willebrand factor (27.6 % of cases) and vascular cell molecules up to 24 months after infection. The concentrations of ICAM-1 and VCAM-1 did not have statistically significant correlations with the degree of compensation of diabetes mellitus (HbA1c level). At various times after COVID-19, cases of ischemic forms of diabetic foot syndrome and thrombosis affecting the cavernous sinus and upper extremities were recorded. Conclusion. Taking into account the results obtained, patients with type 2 diabetes mellitus after SARS-CoV-2 infection require careful monitoring, and, in addition to assessing standard coagulation parameters, determining the level of cell adhesion molecules may have diagnostic value. |
| first_indexed | 2024-03-11T21:38:12Z |
| format | Article |
| id | doaj.art-dc548c3b57c343bda10b0c6b3bcd2378 |
| institution | Directory Open Access Journal |
| issn | 2414-3782 2414-3790 |
| language | English |
| last_indexed | 2024-03-11T21:38:12Z |
| publishDate | 2023-08-01 |
| publisher | Scientia Publishing House |
| record_format | Article |
| series | Juvenis Scientia |
| spelling | doaj.art-dc548c3b57c343bda10b0c6b3bcd23782023-09-26T18:15:00ZengScientia Publishing HouseJuvenis Scientia2414-37822414-37902023-08-0194354110.32415/jscientia_2023_9_4_35-4110.32415/jscientia_2023_9_4_35-41Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19Alieva, A.V.0Republican Specialized Scientific and Practical Medical Center of Endocrinology Named after Academician Y. Kh. TurakulovIntroduction. Damage to the vascular endothelium and hypercoagulation are two of the main causes of post-COVID-19 complications. The aim of our study was to evaluate endothelial dysfunction and thrombotic complications at different periods after COVID-19 in patients with type 2 diabetes mellitus. Patients and methods. We conducted a cross-sectional study of 135 patients with type 2 diabetes mellitus who applied for inpatient treatment at the RSSPMCE clinic (Tashkent, Uzbekistan) in the period from 3 to 24 months after the acute period of COVID-19. The following laboratory parameters were assessed: fibrinogen, INR, APTT, D-dimer, von Willebrand factor, and cell adhesion molecules (VCAM-1, ICAM-1). Results. Despite normal or near-normal INR, APTT and fibrinogen levels, many patients had elevated levels of D-dimer (41.4 % of cases), von Willebrand factor (27.6 % of cases) and vascular cell molecules up to 24 months after infection. The concentrations of ICAM-1 and VCAM-1 did not have statistically significant correlations with the degree of compensation of diabetes mellitus (HbA1c level). At various times after COVID-19, cases of ischemic forms of diabetic foot syndrome and thrombosis affecting the cavernous sinus and upper extremities were recorded. Conclusion. Taking into account the results obtained, patients with type 2 diabetes mellitus after SARS-CoV-2 infection require careful monitoring, and, in addition to assessing standard coagulation parameters, determining the level of cell adhesion molecules may have diagnostic value.https://jscientia.org/index.php/js/user/setLocale/en_US?source=/index.php/js/article/view/205diabetes mellituspost-covid-19 syndromeendothelial dysfunctionhypercoagulationcell adhesion moleculesicam-1vcam-1thrombotic complications |
| spellingShingle | Alieva, A.V. Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19 Juvenis Scientia diabetes mellitus post-covid-19 syndrome endothelial dysfunction hypercoagulation cell adhesion molecules icam-1 vcam-1 thrombotic complications |
| title | Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19 |
| title_full | Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19 |
| title_fullStr | Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19 |
| title_full_unstemmed | Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19 |
| title_short | Indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after COVID-19 |
| title_sort | indicators of endothelial dysfunction and the rate of thrombotic complications in patients with type 2 diabetes mellitus at different periods after covid 19 |
| topic | diabetes mellitus post-covid-19 syndrome endothelial dysfunction hypercoagulation cell adhesion molecules icam-1 vcam-1 thrombotic complications |
| url | https://jscientia.org/index.php/js/user/setLocale/en_US?source=/index.php/js/article/view/205 |
| work_keys_str_mv | AT alievaav indicatorsofendothelialdysfunctionandtherateofthromboticcomplicationsinpatientswithtype2diabetesmellitusatdifferentperiodsaftercovid19 |