Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform
In this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces act...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-02-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/15/3/4658 |
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| author | Wisam Al-Faqheri Fatimah Ibrahim Tzer Hwai Gilbert Thio Norulain Bahari Hamzah Arof Hussin A. Rothan Rohana Yusof Marc Madou |
| author_facet | Wisam Al-Faqheri Fatimah Ibrahim Tzer Hwai Gilbert Thio Norulain Bahari Hamzah Arof Hussin A. Rothan Rohana Yusof Marc Madou |
| author_sort | Wisam Al-Faqheri |
| collection | DOAJ |
| description | In this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces acting on the microfluidic CD (i.e., the centrifugal and capillary forces) to control the burst frequency of the source chamber liquid. For a better understanding of the physics behind the proposed PLV, an analytical model is described. Moreover, three parameters that control the effectiveness of the proposed valve, i.e., the liquid height, liquid density, and venting chamber position with respect to the CD center, are tested experimentally. To demonstrate the ability of the proposed PLV valve, microfluidic liquid switching and liquid metering are performed. In addition, a Bradford assay is performed to measure the protein concentration and evaluated in comparison to the benchtop procedure. The result shows that the proposed valve can be implemented in any microfluidic process that requires simplicity and accuracy. Moreover, the developed valve increases the flexibility of the centrifugal CD platform for passive control of the liquid flow without the need for an external force or trigger. |
| first_indexed | 2024-04-13T08:05:15Z |
| format | Article |
| id | doaj.art-dc577c6ab0bf4eab8249b5c99cffc3cf |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T08:05:15Z |
| publishDate | 2015-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-dc577c6ab0bf4eab8249b5c99cffc3cf2022-12-22T02:55:11ZengMDPI AGSensors1424-82202015-02-011534658467610.3390/s150304658s150304658Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic PlatformWisam Al-Faqheri0Fatimah Ibrahim1Tzer Hwai Gilbert Thio2Norulain Bahari3Hamzah Arof4Hussin A. Rothan5Rohana Yusof6Marc Madou7Centre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaCentre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaCentre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaCentre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaCentre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaCentre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, MalaysiaIn this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces acting on the microfluidic CD (i.e., the centrifugal and capillary forces) to control the burst frequency of the source chamber liquid. For a better understanding of the physics behind the proposed PLV, an analytical model is described. Moreover, three parameters that control the effectiveness of the proposed valve, i.e., the liquid height, liquid density, and venting chamber position with respect to the CD center, are tested experimentally. To demonstrate the ability of the proposed PLV valve, microfluidic liquid switching and liquid metering are performed. In addition, a Bradford assay is performed to measure the protein concentration and evaluated in comparison to the benchtop procedure. The result shows that the proposed valve can be implemented in any microfluidic process that requires simplicity and accuracy. Moreover, the developed valve increases the flexibility of the centrifugal CD platform for passive control of the liquid flow without the need for an external force or trigger.http://www.mdpi.com/1424-8220/15/3/4658centrifugal platformmicrofluidic CDpassive liquid valvepressure equilibriumS-PLVD-PLV |
| spellingShingle | Wisam Al-Faqheri Fatimah Ibrahim Tzer Hwai Gilbert Thio Norulain Bahari Hamzah Arof Hussin A. Rothan Rohana Yusof Marc Madou Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform Sensors centrifugal platform microfluidic CD passive liquid valve pressure equilibrium S-PLV D-PLV |
| title | Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_full | Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_fullStr | Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_full_unstemmed | Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_short | Development of a Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_sort | development of a passive liquid valve plv utilizing a pressure equilibrium phenomenon on the centrifugal microfluidic platform |
| topic | centrifugal platform microfluidic CD passive liquid valve pressure equilibrium S-PLV D-PLV |
| url | http://www.mdpi.com/1424-8220/15/3/4658 |
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