Müller Glia in Retinal Development: From Specification to Circuit Integration
Müller glia of the retina share many features with astroglia located throughout the brain including maintenance of homeostasis, modulation of neurotransmitter spillover, and robust response to injury. Here we present the molecular factors and signaling events that govern Müller glial specification,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2021.815923/full |
| _version_ | 1798024303627730944 |
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| author | Joshua M. Tworig Marla B. Feller Marla B. Feller |
| author_facet | Joshua M. Tworig Marla B. Feller Marla B. Feller |
| author_sort | Joshua M. Tworig |
| collection | DOAJ |
| description | Müller glia of the retina share many features with astroglia located throughout the brain including maintenance of homeostasis, modulation of neurotransmitter spillover, and robust response to injury. Here we present the molecular factors and signaling events that govern Müller glial specification, patterning, and differentiation. Next, we discuss the various roles of Müller glia in retinal development, which include maintaining retinal organization and integrity as well as promoting neuronal survival, synaptogenesis, and phagocytosis of debris. Finally, we review the mechanisms by which Müller glia integrate into retinal circuits and actively participate in neuronal signaling during development. |
| first_indexed | 2024-04-11T18:00:14Z |
| format | Article |
| id | doaj.art-dc59265291634391948239ff0207d940 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-11T18:00:14Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-dc59265291634391948239ff0207d9402022-12-22T04:10:32ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102022-02-011510.3389/fncir.2021.815923815923Müller Glia in Retinal Development: From Specification to Circuit IntegrationJoshua M. Tworig0Marla B. Feller1Marla B. Feller2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United StatesDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United StatesMüller glia of the retina share many features with astroglia located throughout the brain including maintenance of homeostasis, modulation of neurotransmitter spillover, and robust response to injury. Here we present the molecular factors and signaling events that govern Müller glial specification, patterning, and differentiation. Next, we discuss the various roles of Müller glia in retinal development, which include maintaining retinal organization and integrity as well as promoting neuronal survival, synaptogenesis, and phagocytosis of debris. Finally, we review the mechanisms by which Müller glia integrate into retinal circuits and actively participate in neuronal signaling during development.https://www.frontiersin.org/articles/10.3389/fncir.2021.815923/fullmorphogenesisneuronal-glial signalingsynaptogenesistranscription factorNotch |
| spellingShingle | Joshua M. Tworig Marla B. Feller Marla B. Feller Müller Glia in Retinal Development: From Specification to Circuit Integration Frontiers in Neural Circuits morphogenesis neuronal-glial signaling synaptogenesis transcription factor Notch |
| title | Müller Glia in Retinal Development: From Specification to Circuit Integration |
| title_full | Müller Glia in Retinal Development: From Specification to Circuit Integration |
| title_fullStr | Müller Glia in Retinal Development: From Specification to Circuit Integration |
| title_full_unstemmed | Müller Glia in Retinal Development: From Specification to Circuit Integration |
| title_short | Müller Glia in Retinal Development: From Specification to Circuit Integration |
| title_sort | muller glia in retinal development from specification to circuit integration |
| topic | morphogenesis neuronal-glial signaling synaptogenesis transcription factor Notch |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2021.815923/full |
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