Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing
Adiponectin is an adipokine with anti-insulin resistance and anti-inflammatory functions. It exists in serum predominantly in three multimeric complexes: the trimer, hexamer, and high-molecular-weight forms. Although recent studies indicate that adiponectin promotes wound healing in rodents, its rol...
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| Format: | Article |
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MDPI AG
2019-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/10/1134 |
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| author | Jiyoon Ryu Colleen A. Loza Huan Xu Min Zhou Jason T. Hadley Jielei Wu Huayu You Huaiqing Wang Jihong Yang Juli Bai Feng Liu Christie Bialowas Lily Q. Dong |
| author_facet | Jiyoon Ryu Colleen A. Loza Huan Xu Min Zhou Jason T. Hadley Jielei Wu Huayu You Huaiqing Wang Jihong Yang Juli Bai Feng Liu Christie Bialowas Lily Q. Dong |
| author_sort | Jiyoon Ryu |
| collection | DOAJ |
| description | Adiponectin is an adipokine with anti-insulin resistance and anti-inflammatory functions. It exists in serum predominantly in three multimeric complexes: the trimer, hexamer, and high-molecular-weight forms. Although recent studies indicate that adiponectin promotes wound healing in rodents, its role in the wound healing process in humans is unknown. This study investigated the expression levels of adiponectin in adipose tissue and serum of women who experienced either normal or delayed wound healing after abdominal plastic surgery. We found that obese women with delayed healing had slightly lower total adiponectin levels in their adipose tissue compared with women with normal healing rates. Among the different isoforms of adiponectin, levels of the trimer forms were significantly reduced in adipose tissue, but not the serum, of obese women with delayed healing compared to women who healed normally. This study provides clinical evidence for a potential role of low-molecular-weight oligomers of adiponectin in the wound healing process as well as implications for an autocrine and/or paracrine mechanism of adiponectin action in adipose tissues. |
| first_indexed | 2024-03-12T07:22:41Z |
| format | Article |
| id | doaj.art-dc598ff8a7ac4ebfb813d55814c9aef9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:22:41Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-dc598ff8a7ac4ebfb813d55814c9aef92023-09-02T22:17:17ZengMDPI AGCells2073-44092019-09-01810113410.3390/cells8101134cells8101134Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound HealingJiyoon Ryu0Colleen A. Loza1Huan Xu2Min Zhou3Jason T. Hadley4Jielei Wu5Huayu You6Huaiqing Wang7Jihong Yang8Juli Bai9Feng Liu10Christie Bialowas11Lily Q. Dong12Department of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADepartment of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USADivision of Plastic Surgery, Department of Surgery, Albany Medical Center, 50 New Scotland Ave, 1st Floor, Albany, NY 12208-3403, USADepartment of Cell Systems & Anatomy, University of Texas Health Science Center, San Antonio, TX 78229-3900, USAAdiponectin is an adipokine with anti-insulin resistance and anti-inflammatory functions. It exists in serum predominantly in three multimeric complexes: the trimer, hexamer, and high-molecular-weight forms. Although recent studies indicate that adiponectin promotes wound healing in rodents, its role in the wound healing process in humans is unknown. This study investigated the expression levels of adiponectin in adipose tissue and serum of women who experienced either normal or delayed wound healing after abdominal plastic surgery. We found that obese women with delayed healing had slightly lower total adiponectin levels in their adipose tissue compared with women with normal healing rates. Among the different isoforms of adiponectin, levels of the trimer forms were significantly reduced in adipose tissue, but not the serum, of obese women with delayed healing compared to women who healed normally. This study provides clinical evidence for a potential role of low-molecular-weight oligomers of adiponectin in the wound healing process as well as implications for an autocrine and/or paracrine mechanism of adiponectin action in adipose tissues.https://www.mdpi.com/2073-4409/8/10/1134humanwomanadiponectinwound healingmultimers |
| spellingShingle | Jiyoon Ryu Colleen A. Loza Huan Xu Min Zhou Jason T. Hadley Jielei Wu Huayu You Huaiqing Wang Jihong Yang Juli Bai Feng Liu Christie Bialowas Lily Q. Dong Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing Cells human woman adiponectin wound healing multimers |
| title | Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing |
| title_full | Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing |
| title_fullStr | Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing |
| title_full_unstemmed | Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing |
| title_short | Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing |
| title_sort | potential roles of adiponectin isoforms in human obesity with delayed wound healing |
| topic | human woman adiponectin wound healing multimers |
| url | https://www.mdpi.com/2073-4409/8/10/1134 |
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