The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children
Background: Epilepsy is a widespread neurological illness with significant medical, social, and psychological implications. Valproate, Oxcarbazepine, and Levetiracetam are the most regularly used long-term antiepileptic drugs (AEDs) in children today. Objectives: To assess the effect of Valproate,...
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2022-07-01
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| Series: | SVU - International Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://svuijm.journals.ekb.eg/article_243184.html |
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| author | Manish Ajmariya Deepak Sinha Puneet Agrawal Abhishek Mehta* Deepika Singh |
| author_facet | Manish Ajmariya Deepak Sinha Puneet Agrawal Abhishek Mehta* Deepika Singh |
| author_sort | Manish Ajmariya |
| collection | DOAJ |
| description | Background: Epilepsy is a widespread neurological illness with significant medical, social, and psychological implications. Valproate, Oxcarbazepine, and Levetiracetam are the most regularly used long-term antiepileptic drugs (AEDs) in children today.
Objectives: To assess the effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function of children with epilepsy.
Patients and method: This prospective observational study was carried out from May 2019 to December 2020 involving children of age group 1-12 years. Any child with newly diagnosed epilepsy being started on monotherapy with Levetiracetam/Valproate/Oxcarbazepine was included in the study. Their baseline thyroid profile and thyroid function at 6th month and 12th month of starting the antiepileptics were evaluated through Biochemical parameters -T3, T4 & TSH. These values were analyzed and compared by applying paired t-test to determine the effect of antiepileptic therapy on the thyroid function of the study subjects.
Results: In the study, a total of 66 study participants were included of which 51 (77.3%) were males and 15 (22.7%) females. Among the study participants, generalized tonic-clonic seizures were seen in 36 (55%) study participants. As an antiepileptic treatment, Valproate was administered to 34 (51.5%), levetiracetam to 24 (36.4%), and oxcarbazepine to 8 (12.1%) of the study participants. Mean values of TSH, total T3, and total T4 scores at baseline were 1.7, 3.04, and 8.05 respectively; at 6 months were 3.17, 3.4, and 1.4 respectively, at 12 months were 4.9, 3.2, and 5.9. A significant increase in TSH and decrease in T4 values as compared to baseline levels was observed after antiepileptic therapy in the target group indicating a suppressive effect on thyroid function.
Conclusion: This study has depicted a significant negative effect of anti-epileptic therapy on thyroid function in children. |
| first_indexed | 2024-04-13T17:41:57Z |
| format | Article |
| id | doaj.art-dc5a1b8820dd4ce1ab9127a25a320482 |
| institution | Directory Open Access Journal |
| issn | 2735-427X 2636-3402 |
| language | English |
| last_indexed | 2024-04-13T17:41:57Z |
| publishDate | 2022-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj.art-dc5a1b8820dd4ce1ab9127a25a3204822022-12-22T02:37:09ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022022-07-0152318328DOI:10.21608/SVUIJM.2022.136476.1307 The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic childrenManish Ajmariya0 Deepak Sinha1 Puneet Agrawal2 Abhishek Mehta*3 Deepika Singh4Department of Pediatrics, Govt. Medical College, Datia Aman colony, NH#75, Datia (MP)-475661, India.Department of Pediatrics, Govt. Medical College, Datia Aman colony, NH#75, Datia (MP)-475661, India.Department of Pediatrics, Govt. Medical College, Datia Aman colony, NH#75, Datia (MP)-475661, India.Department of Microbiology, Govt. Medical College, Datia Aman colony, NH#75, Datia (MP)-475661, India.Department of Pediatrics, Govt. Medical College, Datia Aman colony, NH#75, Datia (MP)-475661, India.Background: Epilepsy is a widespread neurological illness with significant medical, social, and psychological implications. Valproate, Oxcarbazepine, and Levetiracetam are the most regularly used long-term antiepileptic drugs (AEDs) in children today. Objectives: To assess the effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function of children with epilepsy. Patients and method: This prospective observational study was carried out from May 2019 to December 2020 involving children of age group 1-12 years. Any child with newly diagnosed epilepsy being started on monotherapy with Levetiracetam/Valproate/Oxcarbazepine was included in the study. Their baseline thyroid profile and thyroid function at 6th month and 12th month of starting the antiepileptics were evaluated through Biochemical parameters -T3, T4 & TSH. These values were analyzed and compared by applying paired t-test to determine the effect of antiepileptic therapy on the thyroid function of the study subjects. Results: In the study, a total of 66 study participants were included of which 51 (77.3%) were males and 15 (22.7%) females. Among the study participants, generalized tonic-clonic seizures were seen in 36 (55%) study participants. As an antiepileptic treatment, Valproate was administered to 34 (51.5%), levetiracetam to 24 (36.4%), and oxcarbazepine to 8 (12.1%) of the study participants. Mean values of TSH, total T3, and total T4 scores at baseline were 1.7, 3.04, and 8.05 respectively; at 6 months were 3.17, 3.4, and 1.4 respectively, at 12 months were 4.9, 3.2, and 5.9. A significant increase in TSH and decrease in T4 values as compared to baseline levels was observed after antiepileptic therapy in the target group indicating a suppressive effect on thyroid function. Conclusion: This study has depicted a significant negative effect of anti-epileptic therapy on thyroid function in children.https://svuijm.journals.ekb.eg/article_243184.htmlepilepsy; children; antiepileptic drugs; thyroid function |
| spellingShingle | Manish Ajmariya Deepak Sinha Puneet Agrawal Abhishek Mehta* Deepika Singh The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children SVU - International Journal of Medical Sciences epilepsy; children; antiepileptic drugs; thyroid function |
| title | The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children |
| title_full | The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children |
| title_fullStr | The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children |
| title_full_unstemmed | The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children |
| title_short | The effect of Valproate, Levetiracetam, and Oxcarbazepine monotherapy on thyroid function in epileptic children |
| title_sort | effect of valproate levetiracetam and oxcarbazepine monotherapy on thyroid function in epileptic children |
| topic | epilepsy; children; antiepileptic drugs; thyroid function |
| url | https://svuijm.journals.ekb.eg/article_243184.html |
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