Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CT
Abstract Imaging of bone metastasis response to therapy is a research priority. Stradwin is a new software-tool, with demonstrated sub-voxel accuracy in assessing cortical bone properties from routine CT. We applied this technology to the context of osseous metastases, with particular focus on disea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-08-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-017-0880-2 |
| _version_ | 1798043794641256448 |
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| author | D. Thurtle G. M. Treece T. Barrett V. J. Gnanapragasam |
| author_facet | D. Thurtle G. M. Treece T. Barrett V. J. Gnanapragasam |
| author_sort | D. Thurtle |
| collection | DOAJ |
| description | Abstract Imaging of bone metastasis response to therapy is a research priority. Stradwin is a new software-tool, with demonstrated sub-voxel accuracy in assessing cortical bone properties from routine CT. We applied this technology to the context of osseous metastases, with particular focus on disease progression using prostate cancer as a model. 3D–rendered ‘bone-maps’ were produced for 20 men with advanced prostate cancer, including a sub-cohort of 9 who had undergone serial scans. Correlation between baseline interpretation and assessments of progression between modalities was assessed. Bone-maps took significantly less time to interpret than CT bone windows (P < 0.001). Initial bone-mapping, without adjustment, demonstrated sensitivity and specificity for suspicious areas on CT of 70.7% and 73.1% respectively. Evaluating disease over time, concordance between bone-maps and current practice using RECIST outcomes was 100%. This study demonstrates the feasibility and potential use of this free post-processing software in the serial assessment of osseous metastases. |
| first_indexed | 2024-04-11T22:53:58Z |
| format | Article |
| id | doaj.art-dc5b331d004e4c4ab7e4be7ee351be45 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-11T22:53:58Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-dc5b331d004e4c4ab7e4be7ee351be452022-12-22T03:58:30ZengBMCRadiation Oncology1748-717X2017-08-011211410.1186/s13014-017-0880-2Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CTD. Thurtle0G. M. Treece1T. Barrett2V. J. Gnanapragasam3Academic Urology Group, Department of Surgery, University of CambridgeMedical Imaging Group, Department of Engineering, University of CambridgeCambridge University Hospitals NHS Foundation TrustAcademic Urology Group, Department of Surgery, University of CambridgeAbstract Imaging of bone metastasis response to therapy is a research priority. Stradwin is a new software-tool, with demonstrated sub-voxel accuracy in assessing cortical bone properties from routine CT. We applied this technology to the context of osseous metastases, with particular focus on disease progression using prostate cancer as a model. 3D–rendered ‘bone-maps’ were produced for 20 men with advanced prostate cancer, including a sub-cohort of 9 who had undergone serial scans. Correlation between baseline interpretation and assessments of progression between modalities was assessed. Bone-maps took significantly less time to interpret than CT bone windows (P < 0.001). Initial bone-mapping, without adjustment, demonstrated sensitivity and specificity for suspicious areas on CT of 70.7% and 73.1% respectively. Evaluating disease over time, concordance between bone-maps and current practice using RECIST outcomes was 100%. This study demonstrates the feasibility and potential use of this free post-processing software in the serial assessment of osseous metastases.http://link.springer.com/article/10.1186/s13014-017-0880-2Bone metastasesImaging techniquesMedical imagingProstate cancerComputed tomography3-D imaging |
| spellingShingle | D. Thurtle G. M. Treece T. Barrett V. J. Gnanapragasam Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CT Radiation Oncology Bone metastases Imaging techniques Medical imaging Prostate cancer Computed tomography 3-D imaging |
| title | Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CT |
| title_full | Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CT |
| title_fullStr | Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CT |
| title_full_unstemmed | Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CT |
| title_short | Novel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CT |
| title_sort | novel three dimensional bone mapping software can help assess progression of osseous metastases from routine ct |
| topic | Bone metastases Imaging techniques Medical imaging Prostate cancer Computed tomography 3-D imaging |
| url | http://link.springer.com/article/10.1186/s13014-017-0880-2 |
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