Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma
<b>Objectives</b> : Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC)....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=2;spage=260;epage=265;aulast=Sharma |
| _version_ | 1818048788170801152 |
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| author | Sharma Bhushan Sriram G Saraswathi T Sivapathasundharam B |
| author_facet | Sharma Bhushan Sriram G Saraswathi T Sivapathasundharam B |
| author_sort | Sharma Bhushan |
| collection | DOAJ |
| description | <b>Objectives</b> : Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis. The present study aims at comparison of microvascular density (MVD) and mast cell density (MCD) in normal oral mucosa (NM) and among various grades of OSCC. <b>Materials and Methods</b> : MVD was assessed immunohistochemically using anti-Factor VIII related von Willebrand factor, and MCD using anti-mast cell tryptase in a study sample of 30 cases of OSCC and 10 cases of clinically normal oral mucosa. <b>Results</b> : The mast cells in normal oral mucosa and oral squamous cell carcinoma strongly expressed mast cell tryptase. The density of mast cells and micro vessels were significantly higher in OSCC compared to normal oral mucosa. The MCD and MVD were higher in moderately differentiated OSCC than in well differentiated OSCC ( <i>P</i> > 0.05) and normal oral mucosa ( <i>P</i> < 0.05). Pearson′s correlation revealed a positive correlation between MCD and MVD ( <i>r</i>=0.33; <i>P</i>=0.077). <b>Conclusion</b> : These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase. |
| first_indexed | 2024-12-10T10:27:15Z |
| format | Article |
| id | doaj.art-dc5b751e3dff4102923dd3573f1bb7f8 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-12-10T10:27:15Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-dc5b751e3dff4102923dd3573f1bb7f82022-12-22T01:52:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032010-01-01212260265Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinomaSharma BhushanSriram GSaraswathi TSivapathasundharam B<b>Objectives</b> : Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis. The present study aims at comparison of microvascular density (MVD) and mast cell density (MCD) in normal oral mucosa (NM) and among various grades of OSCC. <b>Materials and Methods</b> : MVD was assessed immunohistochemically using anti-Factor VIII related von Willebrand factor, and MCD using anti-mast cell tryptase in a study sample of 30 cases of OSCC and 10 cases of clinically normal oral mucosa. <b>Results</b> : The mast cells in normal oral mucosa and oral squamous cell carcinoma strongly expressed mast cell tryptase. The density of mast cells and micro vessels were significantly higher in OSCC compared to normal oral mucosa. The MCD and MVD were higher in moderately differentiated OSCC than in well differentiated OSCC ( <i>P</i> > 0.05) and normal oral mucosa ( <i>P</i> < 0.05). Pearson′s correlation revealed a positive correlation between MCD and MVD ( <i>r</i>=0.33; <i>P</i>=0.077). <b>Conclusion</b> : These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase.http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=2;spage=260;epage=265;aulast=SharmaAngiogenesismast cellsmast cell tryptaseoral squamous cell carcinoma |
| spellingShingle | Sharma Bhushan Sriram G Saraswathi T Sivapathasundharam B Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma Indian Journal of Dental Research Angiogenesis mast cells mast cell tryptase oral squamous cell carcinoma |
| title | Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma |
| title_full | Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma |
| title_fullStr | Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma |
| title_full_unstemmed | Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma |
| title_short | Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma |
| title_sort | immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma |
| topic | Angiogenesis mast cells mast cell tryptase oral squamous cell carcinoma |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=2;spage=260;epage=265;aulast=Sharma |
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