Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration
Traditional strategies of bone repair include autografts, allografts and surgical reconstructions, but they may bring about potential hazard of donor site morbidity, rejection, risk of disease transmission and repetitive surgery. Bone tissue engineering (BTE) is a multidisciplinary field that offers...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.587658/full |
| _version_ | 1819175257990234112 |
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| author | Guoke Tang Guoke Tang Guoke Tang Zhihong Tan Wusi Zeng Xing Wang Xing Wang Changgui Shi Yi Liu Yi Liu Hailong He Rui Chen Xiaojian Ye Xiaojian Ye |
| author_facet | Guoke Tang Guoke Tang Guoke Tang Zhihong Tan Wusi Zeng Xing Wang Xing Wang Changgui Shi Yi Liu Yi Liu Hailong He Rui Chen Xiaojian Ye Xiaojian Ye |
| author_sort | Guoke Tang |
| collection | DOAJ |
| description | Traditional strategies of bone repair include autografts, allografts and surgical reconstructions, but they may bring about potential hazard of donor site morbidity, rejection, risk of disease transmission and repetitive surgery. Bone tissue engineering (BTE) is a multidisciplinary field that offers promising substitutes in biopharmaceutical applications, and chitosan (CS)-based bone reconstructions can be a potential candidate in regenerative tissue fields owing to its low immunogenicity, biodegradability, bioresorbable features, low-cost and economic nature. Formulations of CS-based injectable hydrogels with thermo/pH-response are advantageous in terms of their high-water imbibing capability, minimal invasiveness, porous networks, and ability to mold perfectly into an irregular defect. Additionally, CS combined with other naturally-derived or synthetic polymers and bioactive agents has proven to be an effective alternative to autologous bone and dental grafts. In this review, we will highlight the current progress in the development of preparation methods, physicochemical properties and applications of CS-based injectable hydrogels and their perspectives in bone and dental regeneration. We believe this review is intended as starting point and inspiration for future research effort to develop the next generation of tissue-engineering scaffold materials. |
| first_indexed | 2024-12-22T20:52:00Z |
| format | Article |
| id | doaj.art-dc5b7891f3374acb910f88d6b9648651 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-22T20:52:00Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-dc5b7891f3374acb910f88d6b96486512022-12-21T18:13:04ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-09-01810.3389/fbioe.2020.587658587658Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue RegenerationGuoke Tang0Guoke Tang1Guoke Tang2Zhihong Tan3Wusi Zeng4Xing Wang5Xing Wang6Changgui Shi7Yi Liu8Yi Liu9Hailong He10Rui Chen11Xiaojian Ye12Xiaojian Ye13Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Spine Surgery, The Affiliated Zhuzhou Hospital of Xiangya School of Medicine, Central South University (CSU), Hunan, ChinaDepartment of Orthopedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Spine Surgery, The Affiliated Zhuzhou Hospital of Xiangya School of Medicine, Central South University (CSU), Hunan, ChinaDepartment of Spine Surgery, The Affiliated Zhuzhou Hospital of Xiangya School of Medicine, Central South University (CSU), Hunan, ChinaBeijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaDepartment of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Orthopedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Orthopedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaTraditional strategies of bone repair include autografts, allografts and surgical reconstructions, but they may bring about potential hazard of donor site morbidity, rejection, risk of disease transmission and repetitive surgery. Bone tissue engineering (BTE) is a multidisciplinary field that offers promising substitutes in biopharmaceutical applications, and chitosan (CS)-based bone reconstructions can be a potential candidate in regenerative tissue fields owing to its low immunogenicity, biodegradability, bioresorbable features, low-cost and economic nature. Formulations of CS-based injectable hydrogels with thermo/pH-response are advantageous in terms of their high-water imbibing capability, minimal invasiveness, porous networks, and ability to mold perfectly into an irregular defect. Additionally, CS combined with other naturally-derived or synthetic polymers and bioactive agents has proven to be an effective alternative to autologous bone and dental grafts. In this review, we will highlight the current progress in the development of preparation methods, physicochemical properties and applications of CS-based injectable hydrogels and their perspectives in bone and dental regeneration. We believe this review is intended as starting point and inspiration for future research effort to develop the next generation of tissue-engineering scaffold materials.https://www.frontiersin.org/article/10.3389/fbioe.2020.587658/fullchitosaninjectable hydrogelresponsivenessbone repairdental tissue regeneration |
| spellingShingle | Guoke Tang Guoke Tang Guoke Tang Zhihong Tan Wusi Zeng Xing Wang Xing Wang Changgui Shi Yi Liu Yi Liu Hailong He Rui Chen Xiaojian Ye Xiaojian Ye Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration Frontiers in Bioengineering and Biotechnology chitosan injectable hydrogel responsiveness bone repair dental tissue regeneration |
| title | Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration |
| title_full | Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration |
| title_fullStr | Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration |
| title_full_unstemmed | Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration |
| title_short | Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration |
| title_sort | recent advances of chitosan based injectable hydrogels for bone and dental tissue regeneration |
| topic | chitosan injectable hydrogel responsiveness bone repair dental tissue regeneration |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.587658/full |
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