Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis

The research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups: Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis. Group 3 - 50 rats with simulated fecal peritonitis with subsequent anti...

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Main Authors: I. V. Savytskyi, S. V. Tsypoviaz, R. G. Lenik, O. V. Bilash, R. H. Zashchuk, I. V. Miastkivska, L. M. Zaiats
Format: Article
Language:English
Published: Kazimierz Wielki University 2019-06-01
Series:Journal of Education, Health and Sport
Subjects:
Online Access:http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7774
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author I. V. Savytskyi
S. V. Tsypoviaz
R. G. Lenik
O. V. Bilash
R. H. Zashchuk
I. V. Miastkivska
L. M. Zaiats
author_facet I. V. Savytskyi
S. V. Tsypoviaz
R. G. Lenik
O. V. Bilash
R. H. Zashchuk
I. V. Miastkivska
L. M. Zaiats
author_sort I. V. Savytskyi
collection DOAJ
description The research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups: Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis. Group 3 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction and debridement by chlorhexidine solution. Group 4 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction, chlorhexidine debridement and endothelial dysfunction correction with the use of a nitric oxide donor. Fecal peritonitis was modeled using injection of 10% fecal suspension in a dose of 0.5 ml per 100 g of animal weight in the abdominal cavity of laboratory animals by puncture method (Lazarenko V.A., et al., 2016, patent No. 233826). The following results were obtained. Endothelial dysfunction is the trigger mechanism of vascular catastrophes after experiencing experimental peritonitis. Evidence of endothelial functional status impairment during experimental peritonitis is a significant increase in the level of Willebrand factor in the animals blood flow (p
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spelling doaj.art-dc5bb4d9e12c45a392ffe69b2d2f0d9e2022-12-22T02:05:28ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-06-01965725836779Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitisI. V. Savytskyi0S. V. Tsypoviaz1R. G. Lenik2O. V. Bilash3R. H. Zashchuk4I. V. Miastkivska5L. M. Zaiats6Odessa National Medical UniversityOdessa National Medical UniversityState Enterprise Ukrainian Institute for Medicine of Transport of the Ministry of Health of UkraineOdessa National Medical UniversityOdessa National Medical UniversityOdessa National Medical UniversityState Enterprise Ukrainian Institute for Medicine of Transport of the Ministry of Health of UkraineThe research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups: Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis. Group 3 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction and debridement by chlorhexidine solution. Group 4 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction, chlorhexidine debridement and endothelial dysfunction correction with the use of a nitric oxide donor. Fecal peritonitis was modeled using injection of 10% fecal suspension in a dose of 0.5 ml per 100 g of animal weight in the abdominal cavity of laboratory animals by puncture method (Lazarenko V.A., et al., 2016, patent No. 233826). The following results were obtained. Endothelial dysfunction is the trigger mechanism of vascular catastrophes after experiencing experimental peritonitis. Evidence of endothelial functional status impairment during experimental peritonitis is a significant increase in the level of Willebrand factor in the animals blood flow (phttp://www.ojs.ukw.edu.pl/index.php/johs/article/view/7774peritonitisexperimental researchvon willebrand factorerythrocyte intoxication index (eii)leukocyte intoxication index (lii)l-arginin
spellingShingle I. V. Savytskyi
S. V. Tsypoviaz
R. G. Lenik
O. V. Bilash
R. H. Zashchuk
I. V. Miastkivska
L. M. Zaiats
Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis
Journal of Education, Health and Sport
peritonitis
experimental research
von willebrand factor
erythrocyte intoxication index (eii)
leukocyte intoxication index (lii)
l-arginin
title Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis
title_full Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis
title_fullStr Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis
title_full_unstemmed Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis
title_short Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis
title_sort interdependence investigation of dynamic between the von willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis
topic peritonitis
experimental research
von willebrand factor
erythrocyte intoxication index (eii)
leukocyte intoxication index (lii)
l-arginin
url http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7774
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