The special issue on cancer and evolution: Lessons learned
Abstract This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in order to understand why we and other animals get...
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | Evolutionary Applications |
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| Online Access: | https://doi.org/10.1111/eva.13040 |
| _version_ | 1818018660886773760 |
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| author | James DeGregori |
| author_facet | James DeGregori |
| author_sort | James DeGregori |
| collection | DOAJ |
| description | Abstract This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in order to understand why we and other animals get cancer, how it evolves within an individual, and what we can do about it. We can no longer take reductionist approaches that consider only the cancer cells and their genes. Instead, we need to understand how millions of years of evolution have guided strategies that shape cancer risk, why cancer risk varies across different animals, how cancer risk can vary in a population and be influenced by ecology (and influence this ecology), and of course how cancers evolve within us and the evolutionarily informed strategies to counter their impact. My goal here will be to “bring it all home,” providing a refresher of lessons learned with added kibitzing. |
| first_indexed | 2024-04-14T07:42:45Z |
| format | Article |
| id | doaj.art-dc5e8a49a32e4387baa8903d94eb0518 |
| institution | Directory Open Access Journal |
| issn | 1752-4571 |
| language | English |
| last_indexed | 2024-04-14T07:42:45Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Evolutionary Applications |
| spelling | doaj.art-dc5e8a49a32e4387baa8903d94eb05182022-12-22T02:05:27ZengWileyEvolutionary Applications1752-45712020-08-011371784179010.1111/eva.13040The special issue on cancer and evolution: Lessons learnedJames DeGregori0Department of Biochemistry and Molecular Genetics Department of Immunology and Microbiology University of Colorado Anschutz Medical Campus Aurora CO USAAbstract This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in order to understand why we and other animals get cancer, how it evolves within an individual, and what we can do about it. We can no longer take reductionist approaches that consider only the cancer cells and their genes. Instead, we need to understand how millions of years of evolution have guided strategies that shape cancer risk, why cancer risk varies across different animals, how cancer risk can vary in a population and be influenced by ecology (and influence this ecology), and of course how cancers evolve within us and the evolutionarily informed strategies to counter their impact. My goal here will be to “bring it all home,” providing a refresher of lessons learned with added kibitzing.https://doi.org/10.1111/eva.13040cancer evolutioncancer risk and oncogenesissomatic evolutiontransmissible cancers |
| spellingShingle | James DeGregori The special issue on cancer and evolution: Lessons learned Evolutionary Applications cancer evolution cancer risk and oncogenesis somatic evolution transmissible cancers |
| title | The special issue on cancer and evolution: Lessons learned |
| title_full | The special issue on cancer and evolution: Lessons learned |
| title_fullStr | The special issue on cancer and evolution: Lessons learned |
| title_full_unstemmed | The special issue on cancer and evolution: Lessons learned |
| title_short | The special issue on cancer and evolution: Lessons learned |
| title_sort | special issue on cancer and evolution lessons learned |
| topic | cancer evolution cancer risk and oncogenesis somatic evolution transmissible cancers |
| url | https://doi.org/10.1111/eva.13040 |
| work_keys_str_mv | AT jamesdegregori thespecialissueoncancerandevolutionlessonslearned AT jamesdegregori specialissueoncancerandevolutionlessonslearned |