The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas
Inorganic metal ions and the proteins play an essential role in living systems. Different hormones and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc are abundantly distributed in human bodies and play vital role in many biochemical processes. Albumin and...
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National Centre of Excellence in Analytical Chemsitry
2019-12-01
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| Series: | Pakistan Journal of Analytical & Environmental Chemistry |
| Subjects: | |
| Online Access: | http://www.pjaec.pk/index.php/pjaec/article/view/497/307 |
| _version_ | 1818032486416908288 |
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| author | Aisha Munawar Zahid Ali Farzana Muneib Abu Baker Shahid Ahmed Akrem Syed Abid Ali |
| author_facet | Aisha Munawar Zahid Ali Farzana Muneib Abu Baker Shahid Ahmed Akrem Syed Abid Ali |
| author_sort | Aisha Munawar |
| collection | DOAJ |
| description | Inorganic metal ions and the proteins play an essential role in living systems. Different hormones and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc are abundantly distributed in human bodies and play vital role in many biochemical processes. Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out important physiological processes. A disease state or a medical condition can perturb the normal levels of metal ions and proteins in living systems. In the present study, we have analyzed the serum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients. This study includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with age group ranging between 11 to 75 years. During sample collection, only those patients were included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The hyperthyroid state was determined by the correlation of FT3, FT4 and TSH. Serum Fe, Ca and albumin levels were determined by spectrophotometric method, while Zu and Mg by atomic absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results demonstrated the significant differences in the studied parameters as compared to the normal subjects. |
| first_indexed | 2024-12-10T06:08:08Z |
| format | Article |
| id | doaj.art-dc5f4cc8239d4be3a63470d37ef3c4e5 |
| institution | Directory Open Access Journal |
| issn | 1996-918X 2221-5255 |
| language | English |
| last_indexed | 2024-12-10T06:08:08Z |
| publishDate | 2019-12-01 |
| publisher | National Centre of Excellence in Analytical Chemsitry |
| record_format | Article |
| series | Pakistan Journal of Analytical & Environmental Chemistry |
| spelling | doaj.art-dc5f4cc8239d4be3a63470d37ef3c4e52022-12-22T01:59:39ZengNational Centre of Excellence in Analytical ChemsitryPakistan Journal of Analytical & Environmental Chemistry1996-918X2221-52552019-12-01202151160http://dx.doi.org/10.21743/pjaec/2019.12.19The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding AreasAisha Munawar0Zahid Ali1Farzana Muneib2Abu Baker Shahid3Ahmed Akrem4Syed Abid Ali5Department of Chemistry, University of Engineering and Technology, Lahore, Punjab, PakistanDepartment of Chemistry, The University of Lahore, Lahore, Pakistan. Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan.Radio Immuno Assay lab, INMOL Hospital, Lahore, Punjab, Pakistan.Botany Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan, Pakistan. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan. Inorganic metal ions and the proteins play an essential role in living systems. Different hormones and cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zinc are abundantly distributed in human bodies and play vital role in many biochemical processes. Albumin and ferritin are also the most abundant proteins present in our bodies and carrying out important physiological processes. A disease state or a medical condition can perturb the normal levels of metal ions and proteins in living systems. In the present study, we have analyzed the serum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients. This study includes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with age group ranging between 11 to 75 years. During sample collection, only those patients were included for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. The hyperthyroid state was determined by the correlation of FT3, FT4 and TSH. Serum Fe, Ca and albumin levels were determined by spectrophotometric method, while Zu and Mg by atomic absorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained results demonstrated the significant differences in the studied parameters as compared to the normal subjects.http://www.pjaec.pk/index.php/pjaec/article/view/497/307ferritinalbuminhyperthyroidismzincironcalciummagnesium |
| spellingShingle | Aisha Munawar Zahid Ali Farzana Muneib Abu Baker Shahid Ahmed Akrem Syed Abid Ali The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas Pakistan Journal of Analytical & Environmental Chemistry ferritin albumin hyperthyroidism zinc iron calcium magnesium |
| title | The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas |
| title_full | The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas |
| title_fullStr | The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas |
| title_full_unstemmed | The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas |
| title_short | The Impact of Hyperthyroidism on Selected Serum Proteins and Metal Ions in the Population of Lahore and Its Surrounding Areas |
| title_sort | impact of hyperthyroidism on selected serum proteins and metal ions in the population of lahore and its surrounding areas |
| topic | ferritin albumin hyperthyroidism zinc iron calcium magnesium |
| url | http://www.pjaec.pk/index.php/pjaec/article/view/497/307 |
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