FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences
In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigen...
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| Format: | Article |
| Language: | English |
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University of Zagreb Faculty of Food Technology and Biotechnology
2023-01-01
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| Series: | Food Technology and Biotechnology |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/435878 |
| _version_ | 1797206546035245056 |
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| author | Ana-Marija Popović Ana Huđek Turković Kristina Žuna Višnja Bačun-Družina Ivica Rubelj Martina Matovinović |
| author_facet | Ana-Marija Popović Ana Huđek Turković Kristina Žuna Višnja Bačun-Družina Ivica Rubelj Martina Matovinović |
| author_sort | Ana-Marija Popović |
| collection | DOAJ |
| description | In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigenetic influence on the FTO gene as a new approach in the treatment and management of obesity. Several known substances have a positive effect on reducing FTO expression. Depending on which variant of the single nucleotide polymorphism (SNP) is present, the profile and level of gene expression changes. Implementation of environmental change measures could lead to reduced phenotypic manifestation of FTO expression. Treating obesity through FTO gene regulation will have to include various complex signal pathways in which FTO takes part. Identification of FTO gene polymorphisms may be useful for the development of individual obesity management strategies, including the recommendation of taking certain foods and supplements. |
| first_indexed | 2024-04-24T09:08:44Z |
| format | Article |
| id | doaj.art-dc60c9a70f8546df96693d543bd49688 |
| institution | Directory Open Access Journal |
| issn | 1330-9862 1334-2606 |
| language | English |
| last_indexed | 2024-04-24T09:08:44Z |
| publishDate | 2023-01-01 |
| publisher | University of Zagreb Faculty of Food Technology and Biotechnology |
| record_format | Article |
| series | Food Technology and Biotechnology |
| spelling | doaj.art-dc60c9a70f8546df96693d543bd496882024-04-15T18:28:47ZengUniversity of Zagreb Faculty of Food Technology and BiotechnologyFood Technology and Biotechnology1330-98621334-26062023-01-01611142610.17113/ftb.61.01.23.7594FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic InfluencesAna-Marija Popović0Ana Huđek Turković1Kristina Žuna2Višnja Bačun-Družina3Ivica Rubelj4Martina Matovinović5General Hospital Gospić, Kaniška 111, 53000 Gospić, CroatiaFaculty of Food Technology and Biotechnology University of Zagreb, Pierottijeva 6, 10000 Zagreb, CroatiaFaculty of Food Technology and Biotechnology University of Zagreb, Pierottijeva 6, 10000 Zagreb, CroatiaFaculty of Food Technology and Biotechnology University of Zagreb, Pierottijeva 6, 10000 Zagreb, CroatiaRuđer Bošković Institute, Bijenička 54, 10000 Zagreb, CroatiaClinical Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, CroatiaIn this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigenetic influence on the FTO gene as a new approach in the treatment and management of obesity. Several known substances have a positive effect on reducing FTO expression. Depending on which variant of the single nucleotide polymorphism (SNP) is present, the profile and level of gene expression changes. Implementation of environmental change measures could lead to reduced phenotypic manifestation of FTO expression. Treating obesity through FTO gene regulation will have to include various complex signal pathways in which FTO takes part. Identification of FTO gene polymorphisms may be useful for the development of individual obesity management strategies, including the recommendation of taking certain foods and supplements.https://hrcak.srce.hr/file/435878obesityFTO genesingle nucleotide polymorphismsepigenetic influence |
| spellingShingle | Ana-Marija Popović Ana Huđek Turković Kristina Žuna Višnja Bačun-Družina Ivica Rubelj Martina Matovinović FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences Food Technology and Biotechnology obesity FTO gene single nucleotide polymorphisms epigenetic influence |
| title | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
| title_full | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
| title_fullStr | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
| title_full_unstemmed | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
| title_short | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
| title_sort | fto gene polymorphisms at the crossroads of metabolic pathways of obesity and epigenetic influences |
| topic | obesity FTO gene single nucleotide polymorphisms epigenetic influence |
| url | https://hrcak.srce.hr/file/435878 |
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