Tropical Plant Extracts as Potential Antihyperglycemic Agents
Preliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, a-amylase and a-glucosidase inhibition activities were also observed. A correlation between the antihyp...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/17/5/5915 |
| _version_ | 1818515249046749184 |
|---|---|
| author | Cheng Hwee Ming Thamilvaani Manaharan Uma Devi Palanisamy |
| author_facet | Cheng Hwee Ming Thamilvaani Manaharan Uma Devi Palanisamy |
| author_sort | Cheng Hwee Ming |
| collection | DOAJ |
| description | Preliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, a-amylase and a-glucosidase inhibition activities were also observed. A correlation between the antihyperglycemic activity, total phenolic content and antioxidant (DPPH scavenging) activity was established. To further substantiate these findings, the possibility of tannins binding non-specifically to enzymes and thus contributing to the antihyperglycemic activity was also investigated. Our study clearly indicated that the antihyperglycemic activity observed in the plant extracts was indeed not due to non-specific tannin absorption. |
| first_indexed | 2024-12-11T00:26:34Z |
| format | Article |
| id | doaj.art-dc62e69e390e42c89774013292aabdd4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T00:26:34Z |
| publishDate | 2012-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-dc62e69e390e42c89774013292aabdd42022-12-22T01:27:33ZengMDPI AGMolecules1420-30492012-05-011755915592310.3390/molecules17055915Tropical Plant Extracts as Potential Antihyperglycemic AgentsCheng Hwee MingThamilvaani ManaharanUma Devi PalanisamyPreliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, a-amylase and a-glucosidase inhibition activities were also observed. A correlation between the antihyperglycemic activity, total phenolic content and antioxidant (DPPH scavenging) activity was established. To further substantiate these findings, the possibility of tannins binding non-specifically to enzymes and thus contributing to the antihyperglycemic activity was also investigated. Our study clearly indicated that the antihyperglycemic activity observed in the plant extracts was indeed not due to non-specific tannin absorption.http://www.mdpi.com/1420-3049/17/5/5915type 2 diabetes mellitusa-glucosidasea-amylaseantioxidanttotal phenolic content |
| spellingShingle | Cheng Hwee Ming Thamilvaani Manaharan Uma Devi Palanisamy Tropical Plant Extracts as Potential Antihyperglycemic Agents Molecules type 2 diabetes mellitus a-glucosidase a-amylase antioxidant total phenolic content |
| title | Tropical Plant Extracts as Potential Antihyperglycemic Agents |
| title_full | Tropical Plant Extracts as Potential Antihyperglycemic Agents |
| title_fullStr | Tropical Plant Extracts as Potential Antihyperglycemic Agents |
| title_full_unstemmed | Tropical Plant Extracts as Potential Antihyperglycemic Agents |
| title_short | Tropical Plant Extracts as Potential Antihyperglycemic Agents |
| title_sort | tropical plant extracts as potential antihyperglycemic agents |
| topic | type 2 diabetes mellitus a-glucosidase a-amylase antioxidant total phenolic content |
| url | http://www.mdpi.com/1420-3049/17/5/5915 |
| work_keys_str_mv | AT chenghweeming tropicalplantextractsaspotentialantihyperglycemicagents AT thamilvaanimanaharan tropicalplantextractsaspotentialantihyperglycemicagents AT umadevipalanisamy tropicalplantextractsaspotentialantihyperglycemicagents |