Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial
Abstract Aims To investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to evaluate the associations of cardiorenal syndrome with the effects of exer...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13985 |
| _version_ | 1811293422908080128 |
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| author | Knut Asbjørn Rise Langlo Kari Margrethe Lundgren Paolo Zanaboni Rune Mo Øyvind Ellingsen Stein Ivar Hallan Inger‐Lise Aamot Aksetøy Håvard Dalen |
| author_facet | Knut Asbjørn Rise Langlo Kari Margrethe Lundgren Paolo Zanaboni Rune Mo Øyvind Ellingsen Stein Ivar Hallan Inger‐Lise Aamot Aksetøy Håvard Dalen |
| author_sort | Knut Asbjørn Rise Langlo |
| collection | DOAJ |
| description | Abstract Aims To investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to evaluate the associations of cardiorenal syndrome with the effects of exercise. Methods and results Sixty‐nine heart failure patients attended baseline examination, and 61 patients were randomly assigned 1:1 to 3‐month telerehabilitation or control. Data were collected at baseline and 3‐month post‐intervention, including echocardiography and vascular ultrasound, laboratory tests, exercise test with peak oxygen consumption (VO2peak) measurement and 6‐min walk test (6MWT). Baseline VO2peak and 6MWT distance was 0.85 mL*min−1*kg−1 lower and 20 m shorter per 10 mL/min/1.73m2 lower estimated glomerular filtration rate (both P < 0.001). Heart failure patients with cardiorenal syndrome had 3.5 (1.1) mL*min−1*kg−1 lower VO2peak and diastolic dysfunction grade 2–3, and elevated filling pressure was >50% more common compared with those without (all P < 0.05). At the 3‐month post‐intervention follow‐up, only the non‐CRS patients in the intervention group increased VO2peak (0.73 (0.51) mL*min−1*kg−1), whereas VO2peak in the CRS subpopulation of controls decreased (−1.34 (0.43) mL*min−1*kg−1). Cardiorenal syndrome was associated with a decrease in VO2peak in CRS patients compared with non‐CRS patients, −0.91 (0.31) vs. 0.39 (0.35) mL*min−1*kg−1 respectively, P = 0.013. Conclusions Cardiorenal syndrome was negatively associated with VO2peak and 6MWT distance in chronic HF, and the associations were stronger than for heart failure phenotypes and other characteristics. The effect of exercise was negatively associated with cardiorenal syndrome. Exercise seems to be as important in heart failure patients with cardiorenal syndrome, and future studies should include CRS patients to reveal the most beneficial type of exercise. |
| first_indexed | 2024-04-13T05:01:10Z |
| format | Article |
| id | doaj.art-dc63528431c34a59b8858337a52e742f |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-13T05:01:10Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-dc63528431c34a59b8858337a52e742f2022-12-22T03:01:19ZengWileyESC Heart Failure2055-58222022-08-01942215222410.1002/ehf2.13985Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trialKnut Asbjørn Rise Langlo0Kari Margrethe Lundgren1Paolo Zanaboni2Rune Mo3Øyvind Ellingsen4Stein Ivar Hallan5Inger‐Lise Aamot Aksetøy6Håvard Dalen7Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim NorwayDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim NorwayNorwegian Centre for E‐health Research University Hospital of North Norway Tromso NorwayDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim NorwayDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim NorwayDepartment of Nephrology, Clinic of Medicine, St. Olavs hospital Trondheim University Hospital Trondheim NorwayDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim NorwayDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim NorwayAbstract Aims To investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to evaluate the associations of cardiorenal syndrome with the effects of exercise. Methods and results Sixty‐nine heart failure patients attended baseline examination, and 61 patients were randomly assigned 1:1 to 3‐month telerehabilitation or control. Data were collected at baseline and 3‐month post‐intervention, including echocardiography and vascular ultrasound, laboratory tests, exercise test with peak oxygen consumption (VO2peak) measurement and 6‐min walk test (6MWT). Baseline VO2peak and 6MWT distance was 0.85 mL*min−1*kg−1 lower and 20 m shorter per 10 mL/min/1.73m2 lower estimated glomerular filtration rate (both P < 0.001). Heart failure patients with cardiorenal syndrome had 3.5 (1.1) mL*min−1*kg−1 lower VO2peak and diastolic dysfunction grade 2–3, and elevated filling pressure was >50% more common compared with those without (all P < 0.05). At the 3‐month post‐intervention follow‐up, only the non‐CRS patients in the intervention group increased VO2peak (0.73 (0.51) mL*min−1*kg−1), whereas VO2peak in the CRS subpopulation of controls decreased (−1.34 (0.43) mL*min−1*kg−1). Cardiorenal syndrome was associated with a decrease in VO2peak in CRS patients compared with non‐CRS patients, −0.91 (0.31) vs. 0.39 (0.35) mL*min−1*kg−1 respectively, P = 0.013. Conclusions Cardiorenal syndrome was negatively associated with VO2peak and 6MWT distance in chronic HF, and the associations were stronger than for heart failure phenotypes and other characteristics. The effect of exercise was negatively associated with cardiorenal syndrome. Exercise seems to be as important in heart failure patients with cardiorenal syndrome, and future studies should include CRS patients to reveal the most beneficial type of exercise.https://doi.org/10.1002/ehf2.139856‐min walk testChronic heart failureChronic kidney diseaseEchocardiographyExerciseIntervention |
| spellingShingle | Knut Asbjørn Rise Langlo Kari Margrethe Lundgren Paolo Zanaboni Rune Mo Øyvind Ellingsen Stein Ivar Hallan Inger‐Lise Aamot Aksetøy Håvard Dalen Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial ESC Heart Failure 6‐min walk test Chronic heart failure Chronic kidney disease Echocardiography Exercise Intervention |
| title | Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial |
| title_full | Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial |
| title_fullStr | Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial |
| title_full_unstemmed | Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial |
| title_short | Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial |
| title_sort | cardiorenal syndrome and the association with fitness data from a telerehabilitation randomized clinical trial |
| topic | 6‐min walk test Chronic heart failure Chronic kidney disease Echocardiography Exercise Intervention |
| url | https://doi.org/10.1002/ehf2.13985 |
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