Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Scaffolds
Poly(lactide) (PLA) is one of the most investigated semicrystalline polymers for material extrusion (MEX) additive manufacturing (AM) techniques based on polymer melt processing. Research on its application for the development of customized devices tailored to specific anatomical parts of the human...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/19/4057 |
| _version_ | 1797477351279296512 |
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| author | Dario Puppi Gianni Pecorini Gianluca Parrini |
| author_facet | Dario Puppi Gianni Pecorini Gianluca Parrini |
| author_sort | Dario Puppi |
| collection | DOAJ |
| description | Poly(lactide) (PLA) is one of the most investigated semicrystalline polymers for material extrusion (MEX) additive manufacturing (AM) techniques based on polymer melt processing. Research on its application for the development of customized devices tailored to specific anatomical parts of the human body can provide new personalized medicine strategies. This research activity was aimed at testing a new multifunctional AM system for the design and fabrication by MEX of anatomical and dog-bone-shaped PLA samples with different infill densities and deposition angles. In particular, a commercial PLA filament was employed to validate the computer-aided design (CAD) and manufacturing (CAM) process for the development of scaffold prototypes modeled on a human bone defect. Physical-chemical characterization of the obtained samples by <sup>1</sup>H-NMR spectroscopy, size exclusion chromatography (SEC), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) demonstrated a small reduction of polymer molecular weight (~5%) due to thermal processing, as well as that the commercial polymer employed was a semicrystalline poly(<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span>-lactide). Mechanical characterization highlighted the possibility of tuning elastic modulus and strength, as well as the elongation at break up to a 60% value by varying infill parameters. |
| first_indexed | 2024-03-09T21:16:22Z |
| format | Article |
| id | doaj.art-dc658c43f4dd45afbd733ed1912af510 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T21:16:22Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-dc658c43f4dd45afbd733ed1912af5102023-11-23T21:33:32ZengMDPI AGPolymers2073-43602022-09-011419405710.3390/polym14194057Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) ScaffoldsDario Puppi0Gianni Pecorini1Gianluca Parrini2BIOLab Research Group, Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM—Pisa, Via G. Moruzzi 13, 56124 Pisa, ItalyBIOLab Research Group, Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM—Pisa, Via G. Moruzzi 13, 56124 Pisa, ItalyFabrica Machinale, Via Giuntini 13, Cascina, 56021 Pisa, ItalyPoly(lactide) (PLA) is one of the most investigated semicrystalline polymers for material extrusion (MEX) additive manufacturing (AM) techniques based on polymer melt processing. Research on its application for the development of customized devices tailored to specific anatomical parts of the human body can provide new personalized medicine strategies. This research activity was aimed at testing a new multifunctional AM system for the design and fabrication by MEX of anatomical and dog-bone-shaped PLA samples with different infill densities and deposition angles. In particular, a commercial PLA filament was employed to validate the computer-aided design (CAD) and manufacturing (CAM) process for the development of scaffold prototypes modeled on a human bone defect. Physical-chemical characterization of the obtained samples by <sup>1</sup>H-NMR spectroscopy, size exclusion chromatography (SEC), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) demonstrated a small reduction of polymer molecular weight (~5%) due to thermal processing, as well as that the commercial polymer employed was a semicrystalline poly(<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span>-lactide). Mechanical characterization highlighted the possibility of tuning elastic modulus and strength, as well as the elongation at break up to a 60% value by varying infill parameters.https://www.mdpi.com/2073-4360/14/19/4057additive manufacturingpoly(lactide)fused deposition modelinganatomical model |
| spellingShingle | Dario Puppi Gianni Pecorini Gianluca Parrini Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Scaffolds Polymers additive manufacturing poly(lactide) fused deposition modeling anatomical model |
| title | Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Scaffolds |
| title_full | Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Scaffolds |
| title_fullStr | Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Scaffolds |
| title_full_unstemmed | Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Scaffolds |
| title_short | Additive Manufacturing of Anatomical Poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide) Scaffolds |
| title_sort | additive manufacturing of anatomical poly span style font variant small caps d span span style font variant small caps l span lactide scaffolds |
| topic | additive manufacturing poly(lactide) fused deposition modeling anatomical model |
| url | https://www.mdpi.com/2073-4360/14/19/4057 |
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